Table 3 Recommendations on TCA dosing in treatment of unipolar MDD 

Initial dose (mg/day)

25^a, 25-50^b,c or 50-75^d

25-50^b,c or 50-75^f

25-50^b,c

25-50^a,b,c or 50^h

EP^†: 10-30^d or 12.5-25^b

EP: 10^f or 12.5-25^b

Outpatient: 25-75^g

CVD^‡: 10-25^h

Hospitalized: 75-100^g

EP: 10-25^h or 12.5-25^b

EP: 10^g or 12.5-25^b

Maintenance dose (mg/day)

50-200^a,b, 75-200^c

75-250^b, 100-150^c

75-300^f or 100-300^a,c

75-300^b, 100-300^a

or 100-150^d

or max. 250^f

Outpatient: 150-200^g

or max. 150^h

Hospitalized: 100-200^d

EP: 30-50^f

Hospitalized: 200-300^g

EP: 50-150^d

EP: 20-50^g

Therapeutic plasma

50-150^d or 70-170^b,c,e

175–450^§,c or

175–300^§,b,c,e

80–200^§,b,c,e

concentrations (ng/mL)

230–450^§,b,e