Skip to main content

Table 2 The distribution of alleles and genotypes for 5 SNPs between schizophrenia patients and healthy control subjects

From: Association study between genetic variants and the risk of schizophrenia in the Chinese population based on GWAS-implicated 6p21.3–23.1 human genome region: a case-control study

 

SNP

HCsa, Nb(%)

SCZsc, N(%)

ORd (95% CIe)

p

rs107822

 

T

569 (63.9)

564 (62.1)

1.000(ref)

 
 

C

321 (36.1)/(39.6)f

344 (37.9)

1.081 (0.893–1.309)

0.425

codominant

TT

191 (42.9)

185 (40.8)

1.000(ref)

 

CC

67 (15.1)

75 (16.5)

1.156 (0.785–1.701)

0.463

CT

187 (42.0)

194 (42.7)

1.071 (0.805–1.424)

0.637

dominant

TT

191 (42.9)

185 (40.8)

1.000(ref)

 

CC/CT

254 (57.1)

269 (59.2)

1.093 (0.839–1.425)

0.509

recessive

TT- CT

378 (84.9)

379 (83.5)

1.000(ref)

 

CC

67 (15.1)

75 (16.5)

1.116 (0.780–1.599)

0.547

rs383711

 

A

454 (51.0)

451 (49.7)

1.000(ref)

0.569

 

G

436 (49.0)/(49.2)f

457 (50.3)

1.055 (0.877–1.269)

codominant

AA

114 (25.6)

112 (24.7)

1.000(ref)

 

AG

226 (50.8)

227 (50.0)

1.022 (0.743–1.407)

0.892

GG

105 (23.6)

115 (25.3)

1.115 (0.769–1.616)

0.566

dominant

AA

114 (25.6)

112 (24.7)

1.000(ref)

 

AG- GG

331 (74.4)

342 (75.3)

1.052 (0.778–1.422)

0.743

recessive

AA- AG

340 (76.4)

339 (74.7)

1.000(ref)

 

GG

105 (23.6)

115 (25.3)

1.098 (0.810–1.489)

0.545

rs439205

 

A

549 (61.7)

560 (61.7)

1.0000(ref)

 
 

G

341 (38.3)/(39.6)f

348 (38.2)

1.000 (0.827–1.210)

0.996

codominant

AA

174 (39.1)

181 (39.9)

1.000

 

AG

201 (45.2)

198 (43.6)

0.947 (0.711–1.261)

0.709

GG

70 (15.7)

75 (16.5)

1.030 (0.0.700–1.516)

0.881

dominant

AA

174 (39.1)

181 (39.9)

1.000(ref)

 

AG- GG

271 (60.9)

273 (60.1)

0.968 (0.741–1.265)

0.814

recessive

AA- AG

375 (84.3)

379 (83.5)

1.000(ref)

0.748

GG

70 (15.7)

75 (16.5)

1.060 (0.743–1.513)

rs2021722

 

G

827 (92.9)

806 (88.8)

1.000(ref)

 
 

A

63 (7.1)/(10.9)f

102 (11.2)

1.661 (1.196–2.308)

0.002

codominant

GG

384 (86.3)

355 (78.2)

1.000(ref)

 

AA

2 (0.4)

3 (0.7)

1.623 (0.270–9.767)

0.933

AG

59 (13.3)

96 (21.1)

1.760 (1.234–2.510)

0.002

dominant

GG

384 (86.3)

355 (78.2)

1.000(ref)

 

AG-AA

61 (13.7)

99 (21.8)

1.756 (1.237–2.492)

0.002

recessive

GG-AG

443 (99.5)

451 (99.3)

1.000(ref)

0.670

AA

2 (0.4)

3 (0.7)

1.473 (0.245–8.860)

rs421446

 

G

598 (67.2)

607 (66.8)

1.000(ref)

 
 

A

292 (32.8)/(38.3)f

301 (33.1)

1.016 (0.834–1.236)

0.878

codominant

GG

196 (44.0)

204 (44.9)

1.000(ref)

 

AG

206 (46.3)

199 (43.8)

0.928 (0.704–1.224)

0.597

AA

43 (9.7)

51 (11.2)

1.140 (0.726–1.788)

0.570

dominant

GG

196 (44.0)

204 (44.9)

1.000(ref)

 

AG- AA

249 (56.0)

250 (55.1)

0.965 (0.741–1.255)

0.789

recessive

GG- AG

402 (90.3)

403 (88.8)

1.000(ref)

 

AA

43 (9.7)

51 (11.2)

1.183 (0.771–1.816)

0.442

  1. Notes: aHC Healthy controls, bN number of the group, cSCZ Schizophrenia patient, dOR Odds ratio, eCI Confidence interval, f = the number in the bracket behind the slash is minor allele frequency in East Asian sample (EAS), data are based on NCBI SNPdatabase (http://www.ncbi.nlm.nih.gov/snp/; accessed on 10 June 2021)