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Table 5 Comparison of SCL-90-R score, psychosis phenotype, and clinical diagnosis between Classes (n = 939)

From: Testing extra-linearity across a psychosis continuum

 

Class 1

(High Risk)

N = 490 (52.2%)

Class 2

(Depression)

N = 337 (35.9%)

Class 3

(Prototypical Scizophrenia)

N = 51

(5.4%)

Class 4

(Schizophrenia/Depression)

N = 61

(6.5%)

Class 1

β(95%CI)

Class 2

β(95%CI)

Class 3

β(95%CI)

Class 4

β(95%CI)

Class 4 vs.3

β(95%CI)

Psychotic Experiences

(SCL-90-R)

27.40 ± 4.45

29.30 ± 5.45

39.67 ± 10.35

42.80 ± 10.17

0 (ref)

1.91***$

(1.11–2.72)

12.26***$

(10.6–13.93)

15.42***$

(13.88–16.97)

2.93

(−0.9–6.76)

Paranoid ideation subscale

11.00 ± 2.96

11.12 ± 3.39

15.18 ± 4.15

16.15 ± 4.18

0 (ref)

0.10

(−0.35–0.56)

4.18***$

(3.23–5.12)

5.13***$

(4.25–6.00)

0.85

(− 0.70–2.39)

Psychoticism subscale

16.40 ± 3.56

18.18 ± 4.23

24.49 ± 6.48

26.66 ± 6.70

0 (ref)

1.81***$

(1.22–2.40)

8.09***$

(6.86–9.32)

10.29***$

(9.16–11.43)

2.08

(− 0.39–4.56)

     

Class 1

OR(95%CI)

Class 2

OR (95%CI)

Class 3

OR (95%CI)

Class 4

OR (95%CI)

Class 4 vs.3

OR (95%CI)

Hallucinations and Delusions

115 (23.5%)

38 (11.3%)

27 (52.9%)

34 (55.7%)

1 (ref)

0.40***$

(0.27–0.60)

3.71***$

(2.05–6.72)

3.93***$

(2.26–6.85)

1.07

(0.50–2.27)

Schizophrenia nuclear symptoms

131 (26.7%)

66 (19.6%)

50 (98.0%)

55 (90.2%)

1 (ref)

0.65*

(0.47–0.92)

144.17***$

(19.68–1056.25)

26.35***$

(11.03–62.96)

0.21

(0.02–1.84)

Nuclear symptoms and Depression

0 (0%)

37 (11%)

0 (0%)

45 (73.8%)

1 (ref)

n.a.

n.a.

n.a.

n.a.

Depression (cutoff)

0 (0%)

195 (57.9%)

0 (0%)

51 (83.6%)

1 (ref)

n.a.

n.a.

n.a.

n.a.

Diagnosed Schizophrenia

4 (0.8)

7 (2.1)

1 (2.0)

2 (3.3)

1 (ref)

2.57 (0.74–8.92)

2.14 (0.23–19.97)

3.13

(0.53–18.53

1.38

(0.11–17.44)

Diagnosed Non-Psychotic Disorder

90 (18.4)

99 (29.4)

11 (21.6)

20 (32.8)

1 (ref)

1.84***$

(1.33–2.56)

1.21

(0.60–2.45)

2.09* (1.17–3.75)

1.72

(0.71–4.16)

  1. Adjusted for age and sex
  2. $: significance after correction for regressions of 21 variables using Bonferroni’s correction and the new threshold is 0.05/21 = 0.0024