Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder

BMC Psychiatry

Table 4 Association of suicidal ideation with serum Cys C in MDD patients

Cys C quartile	n	Conc range, mg/L	EXP(β), OR(95%CI)
Cys C quartile	n	Conc range, mg/L	Crude	Model 1	Model 2
Quartile 1 (low)	36	< −0.12	Reference	Reference	Reference
Quartile 2	29	−0.12 to − 0.08	0.780, 2.182 (0.794-5.994)	1.102, 3.009 (0.988-9.162)	1.205, 3.335 (0.949-11.722)
Quartile 3	35	−0.08 to − 0.03	0.965, 2.625 (0.888-7.762)	1.202, 3.325 (0.998-11.082)	1.280, 3.595 (0.874-14.779)
Quartile 4 (high)	30	> −0.03	1.421, 4.143 (1.389-12.352)	1.733, 5.657 (1.531-20.902)	2.278, 9.753 (1.520-62.575)
P for trend			0.011	0.011	0.015

Logistic regression was used to examine the associations between serum levels of Cys C and suicidal ideation. Serum Cys C was divided into quartiles (quartile 4: ≥75th, quartile 3: 50–75th, quartile 2: 25–50th, quartile 1: < 25th percentile)
Crude no adjustment
Model 1 adjusted for age (log-transformed), gender distribution, smoking, alcohol consumption, family history of depression and traumatic life events
Model 2 adjusted for the same variables as Model 1 as well as Urea (log-transformed), Cr (log-transformed), UA (log-transformed), eGFR (log-transformed) and hs-CRP (log-transformed)

ISSN: 1471-244X