| Instrument | Baseline | End of treatment | 2 year FU | 4 year FU |
---|---|---|---|---|---|
Demographic background | |||||
 • Age; sex; cultural background/identity | YIT-Q | X |  |  |  |
 • Family educational level and socioeconomic status | YIT-Q | X |  |  |  |
Substance use | |||||
 • Lifetime and recent substance use | MATE-Y | X |  | X | X |
 • DSM-5 substance use disorder (SUD); age of onset | MATE-Y | X |  | X | X |
Non-SUD mental disorders | |||||
 • DSM-5 lifetime and past-year mental disorders; age of onset | Structured DSM-5 interview | X |  | X | X |
 • Dimensional measures of mental health problems, including depression, anxiety, stress; prodromal psychotic symptoms; personality risk for substance abuse; intellectual disability | DASS-21; PQ-16; | X |  | X | X |
SURPS; SCIL | X | Â | Â | Â | |
 • Suicidal ideation/attempts | MINI |  |  | X | X |
Family history/environment | |||||
 • History of SUD (parents; grandparents; siblings) | YIT-Q | X |  |  |  |
 • History of non-SUD mental disorders; criminality, violence, abuse, neglect, homelessness | YIT-Q | X |  |  |  |
YIT-Q | X | Â | Â | Â | |
Life events | |||||
 • Traumatic life events | Structured DSM-5 interview | X |  | X | X |
 • Turning points with major impact on addiction course | YIT-Q |  |  | X | X |
Social functioning | |||||
 • Youth’s functioning in the areas of: education; employment; living arrangements; social relationships/support; delinquency | YIT-Q | X |  | X | X |
 • General functioning, disability and quality of life | WHODAS-2.0 | X |  | X | X |
Treatment history | |||||
 • Number/types of earlier addiction and mental health treatments | YIT-Q | X |  | X | X |
 • Intention/motivation for current treatment | YIT-Q | X |  |  |  |
Endophenotype and biomarker | |||||
 • Behavioral measures of impulsivity (computerized tasks) | Risky Gains task, VBDM, Self-Ordered Pointing task | X |  | X | X |
 • Biomarkers of chronic stress: hair cortisol and testosterone | Hair sample analysis | X |  | X | X |
Index treatment characteristics | |||||
 • Type, intensity, duration of current treatment received and initial treatment responsea |  |  | X |  |  |