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Table 3 Interaction effects between FKBP5 polymorphisms and parenting style on depressive symptoms

From: Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

Interaction item

Model 1

Model 2

OR (95% CI)

P value

Adjusted OR (95% CI)

P value

rs7757037

 rs7757037 × parenting style of the father

  Codominant model

AA vs. GG

5.35 (1.15–24.8)

0.032

4.62 (0.90–23.85)

0.067

AG vs. GG

6.04 (1.36–26.94)

0.018*

5.13 (1.05–25.06)

0.043

  Dominant model

AA+AG vs. GG

5.78 (1.34–24.96)

0.019*

4.94 (1.05–23.27)

0.043

  Recessive model

AA vs. AG + GG

1.05 (0.51–2.18)

0.890

1.06 (0.47–2.40)

0.889

 rs7757037 × parenting style of the mother

  Codominant model

AA vs. GG

0.70 (0.11–4.43)

0.702

0.22 (0.03–1.65)

0.139

AG vs. GG

0.72 (0.12–4.21)

0.715

0.26 (0.04–1.75)

0.165

  Dominant model

AA+AG vs. GG

0.71 (0.13–4.02)

0.703

0.25 (0.04–1.60)

0.142

  Recessive model

AA vs. AG + GG

0.87 (0.32–2.36)

0.783

0.67 (0.22–2.05)

0.478

rs2817032

 rs2817032 × parenting style of the father

  Codominant model

TT vs. CC

NA

NA

NA

NA

TC vs. CC

NA

NA

NA

NA

  Dominant model

TT + TC vs. CC

NA

NA

NA

NA

  Recessive model

TT vs. TC + CC

1.10 (0.56–2.15)

0.784

1.04 (0.49–2.21)

0.912

 rs2817032 × parenting style of the mother

  Codominant model

TT vs. CC

NA

NA

NA

NA

TC vs. CC

NA

NA

NA

NA

  Dominant model

TT + TC vs. CC

NA

NA

NA

NA

  Recessive model

TT vs. TC + CC

0.98 (0.37–2.57)

0.969

0.61 (0.21–1.79)

0.372

rs2817035

 rs2817035 × parenting style of the father

  Codominant model

GG vs. AA

7.60 (0.71–81.21)

0.094

8.30 (0.70–97.85)

0.093

GA vs. AA

7.50 (0.70–80.67)

0.097

7.95 (0.66–95.40)

0.102

  Dominant model

GG + GA vs. AA

7.43 (0.71–77.64)

0.094

8.14 (0.71–93.65)

0.093

  Recessive model

GG vs. GA + AA

1.10 (0.56–2.14)

0.787

1.15 (0.54–2.45)

0.714

 rs2817035 × parenting style of the mother

  Codominant model

GG vs. AA

NA

NA

NA

NA

GA vs. AA

NA

NA

NA

NA

  Dominant model

GG + GA vs. AA

NA

NA

NA

NA

  Recessive model

GG vs. GA + AA

1.19 (0.46–3.05)

0.722

0.90 (0.32–2.58)

0.850

  1. Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; NA, not applicable or not available
  2. Model 1: unadjusted models
  3. Model 2: adjusted for age, gender, living arrangement, and morning cortisol level
  4. *: Gene-environment interactions, which remained significant after correcting for multiple testing