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Table 3 Interaction effects between FKBP5 polymorphisms and parenting style on depressive symptoms

From: Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

Interaction item Model 1 Model 2
OR (95% CI) P value Adjusted OR (95% CI) P value
rs7757037
 rs7757037 × parenting style of the father
  Codominant model AA vs. GG 5.35 (1.15–24.8) 0.032 4.62 (0.90–23.85) 0.067
AG vs. GG 6.04 (1.36–26.94) 0.018* 5.13 (1.05–25.06) 0.043
  Dominant model AA+AG vs. GG 5.78 (1.34–24.96) 0.019* 4.94 (1.05–23.27) 0.043
  Recessive model AA vs. AG + GG 1.05 (0.51–2.18) 0.890 1.06 (0.47–2.40) 0.889
 rs7757037 × parenting style of the mother
  Codominant model AA vs. GG 0.70 (0.11–4.43) 0.702 0.22 (0.03–1.65) 0.139
AG vs. GG 0.72 (0.12–4.21) 0.715 0.26 (0.04–1.75) 0.165
  Dominant model AA+AG vs. GG 0.71 (0.13–4.02) 0.703 0.25 (0.04–1.60) 0.142
  Recessive model AA vs. AG + GG 0.87 (0.32–2.36) 0.783 0.67 (0.22–2.05) 0.478
rs2817032
 rs2817032 × parenting style of the father
  Codominant model TT vs. CC NA NA NA NA
TC vs. CC NA NA NA NA
  Dominant model TT + TC vs. CC NA NA NA NA
  Recessive model TT vs. TC + CC 1.10 (0.56–2.15) 0.784 1.04 (0.49–2.21) 0.912
 rs2817032 × parenting style of the mother
  Codominant model TT vs. CC NA NA NA NA
TC vs. CC NA NA NA NA
  Dominant model TT + TC vs. CC NA NA NA NA
  Recessive model TT vs. TC + CC 0.98 (0.37–2.57) 0.969 0.61 (0.21–1.79) 0.372
rs2817035
 rs2817035 × parenting style of the father
  Codominant model GG vs. AA 7.60 (0.71–81.21) 0.094 8.30 (0.70–97.85) 0.093
GA vs. AA 7.50 (0.70–80.67) 0.097 7.95 (0.66–95.40) 0.102
  Dominant model GG + GA vs. AA 7.43 (0.71–77.64) 0.094 8.14 (0.71–93.65) 0.093
  Recessive model GG vs. GA + AA 1.10 (0.56–2.14) 0.787 1.15 (0.54–2.45) 0.714
 rs2817035 × parenting style of the mother
  Codominant model GG vs. AA NA NA NA NA
GA vs. AA NA NA NA NA
  Dominant model GG + GA vs. AA NA NA NA NA
  Recessive model GG vs. GA + AA 1.19 (0.46–3.05) 0.722 0.90 (0.32–2.58) 0.850
  1. Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; NA, not applicable or not available
  2. Model 1: unadjusted models
  3. Model 2: adjusted for age, gender, living arrangement, and morning cortisol level
  4. *: Gene-environment interactions, which remained significant after correcting for multiple testing