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Table 1 Input parameters for the model. Costs are displayed in British pounds (GBP) 2019

From: Cost-utility analysis of esketamine and electroconvulsive therapy in adults with treatment-resistant depression

  ECT Source Esketamine Source
Transition probability
 Depression to remission (tpA2B)a and (tpC2B) 0.696 (28) 0.392 (27)
 Remission to depression (tpB2C) 0.108 (28) 0.0724 (26)
 Remission to depression (tpB2C) for maintenance ECT 0.0300 (29)   
Transition probability for both ECT and esketamine
 Depression to death (tpA2G), (tpC2G) and (tpD2G) 0.00304 (31, 32)
 Depression to remission (tpD2E) 0.107 (30)
 Remission to depression (tpE2D) 0.232 (30)
Remission to death (tpB2G and tpE2G) both ECT and esketamine
 45–49 0.000180 Lifetable
 50–54 0.000265 Lifetable
 55–59 0.000407 Lifetable
 60–64 0.000646 Lifetable
 65–69 0.00100 Lifetable
 70–74 0.00163 Lifetable
 75–79 0.00285 Lifetable
Utility per cycle
 Remission 0.07 (33)
 Depression 0.05 (33)
Cost per state and cycle age < 65 (age ≥ 65)
 State A and C 7932 (6321)   7210 (5599)  
 State B, standard treatment after ECT 701 (118)   
 State B, month 1 M-ECT and esketamine 3313 (2730)   2882 (2299)  
 State B, month 2 and following months M-ECT and month 2–5 esketamine 2161 (1578)   1583 (1000)  
 State B, month 6 esketamine   1890 (1307)  
 State D 2729 (1119)   2729 (1119)  
 State E and F 701 (118)   701 (118)  
  1. a tp = transition probability, that is, the probability of the individual moving from one state to the other. tpA2B indicates the probability of the individual transitioning from state A (depression) to state B (remission)