Number of prior relapses | Primary proxy | Secondary proxy 1 | ||||
---|---|---|---|---|---|---|
Patients, na | Median time to next relapse, years | HR (95% CI)b | Patients, na | Median time to next relapse, years | HR (95% CI)b | |
0 | 2994 | 1.52 | - | 2993 | - | - |
1 | 2024 | 1.23 | 1.84 (1.71–1.99) | 779 | 6.47 | 2.76 (2.39–3.18) |
2 | 1278 | 0.89 | 2.77 (2.53–3.03) | 278 | 2.26 | 6.10 (5.00–7.43) |
3 | 829 | 0.85 | 3.55 (3.19–3.94) | 128 | 1.80 | 5.69 (4.32–7.48) |
4 | 530 | 0.59 | 5.06 (4.48–5.73) | 60 | 0.72 | 10.11 (7.03–14.54) |
5 | 362 | 0.46 | 6.38 (5.53–7.37) | 32 | 1.23 | 10.82 (6.77–17.31) |
6 | 248 | 0.44 | 6.98 (5.89–8.27) | 19 | 1.08 | 7.55 (3.72–15.32) |
7 | 164 | 0.43 | 9.55 (7.79–11.70) | 8 | 0.84 | 16.92 (6.95–41.22) |
8 | 109 | 0.51 | 9.23 (7.21–11.81) | 5 | 1.31 | 13.72 (4.37–43.11) |
9 | 71 | 0.39 | 11.59 (8.69–15.47) | 3 | 0.07 | 35.98 (11.34–114.20) |
10 | 49 | 0.22 | 18.65 (15.42–22.56) | 3 | 0.04 | 10.02 (2.48–40.48) |