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Fig. 6 | BMC Psychiatry

Fig. 6

From: Transdiagnostic symptom subtypes across autism spectrum disorders and attention deficit hyperactivity disorder: validated by measures of neurocognition and structural connectivity

Fig. 6

The hypothesis of the neuroimage- cognitions- ASD/ADHD symptoms. Note:Model 1 indicating that C1 and C2 are, in fact, different manifestations of the same overarching disorder with shared neuroimaging etiology. The manifestations range from C2 with few social symptoms to C1 as the most severe subtype characterized by severe social and ADHD problems. Model 2 proposed that cognitive endophenotypic traits mediate between C2/C3 subtypes distinct social symptoms and certain neuroimage abnormality. Model 3 demonstrated that the cognitive endophenotype is useful for mediating the associations between WM structural abnormality and ASD-ADHD spectrum. Differentiating between Models 2 and 3 is weather cognitive endophenotype and symptom are overlapping in subtypes

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