Table 2 Antipsychotic medication type, supply, and adherence by payer group and index antipsychotic weight gain risk profile

Medication type (N, %)

 Second-generation antipsychotics

2,413 (87.8%)

1,919 (99.2%)*

494 (61.9%)*

7,367 (84.2%)

5,964 (99.3%)*

1,393 (52.3%)*

 Lurasidone

47 (1.7%)

16 (0.8%)*

31 (3.9%)*

176 (2.0%)

41 (0.7%)*

135 (5.1%)*

 Aripiprazole

485 (17.7%)

140 (7.2%)*

345 (43.2%)*

924 (10.6%)

192 (3.2%)*

732 (27.5%)*

 Olanzapine

553 (20.1%)

553 (28.6%)*

0 (0.0%)*

1,209 (13.8%)

1,209 (20.1%)*

0 (0.0%)*

 Paliperidone

127 (4.6%)

127 (6.6%)*

0 (0.0%)*

791 (9.0%)

791 (13.2%)*

0 (0.0%)*

 Quetiapine

429 (15.6%)

429 (22.2%)*

0 (0.0%)*

1,532 (17.5%)

1,532 (25.5%)*

0 (0.0%)*

 Risperidone

1,001 (36.4%)

1,001 (51.8%)*

0 (0.0%)*

2,871 (32.8%)

2,871 (47.8%)*

0 (0.0%)*

 Ziprasidone

176 (6.4%)

59 (3.1%)*

117 (14.7%)*

669 (7.7%)

162 (2.7%)*

507(19.0%)*

 Other

39 (1.4%)

22 (1.1%)*

17 (2.1%)*

138 (1.6%)

77 (1.3%)*

61 (2.3%)*

 First-generation antipsychotics

521 (19.0%)

174 (9.0%)*

331 (41.5%)*

2,142 (24.5%)

652 (10.9%)*

1,421 (53.3%)*

 Haloperidol

272 (9.9%)

100 (5.2%)*

172 (21.6%)*

1,451 (16.6%)

433 (7.2%)*

1,018 (38.2%)*

 Thiothixene

36 (1.3%)

6 (0.3%)*

30 (3.8%)*

-

-

-

 Fluphenazine

94 (3.4%)

24 (1.2%)*

70 (8.8%)*

370 (4.2%)

97 (1.6%)*

273 (10.2%)*

 Trifluoperazine

29 (1.1%)

5 (0.3%)*

24 (3.0%)*

-

-

-

 Perphenazine

45 (1.6%)

16 (0.8%)*

29 (3.6%)*

109 (1.3%)

29 (0.5%)*

80 (3.0%)*

 Chlorpromazine

26 (1.0%)

26 (1.3%)*

0 (0.0%)*

-

-

-

 Other

26 (1.0%)

5 (0.3%)*

12 (1.5%)*

199 (2.3%)

111 (1.9%)*

73(2.7%)*

Route of administration (N, %)

 Oral

2,605 (94.8%)

1,890 (97.7%)*

705 (88.4%)*

7,615 (87.1%)

5,548 (92.4%)*

2,042 (76.6%)*

 LAI

235 (8.6%)

143 (7.4%)*

92 (11.5%)*

1,694 (19.4%)

1,006 (16.8%)*

688 (25.8%)*

 Other

76 (2.8%)

40 (2.1%)*

30 (3.8%)*

330 (3.8%)

95 (1.6%)*

181 (6.8%)*

Medication supply and regimen type

 Index Antipsychotic Days Supply (Mean, SD)

35.1 (23.2)

33.7 (21.7)*

38.5 (25.7)*

27.4 (8.8)

27.9 (7.8)*

26.8 (10.0)*

 Monotherapy

2,192 (79.8%)

1,427 (73.8%)*

749 (93.9%)*

7,158 (81.8%)

4,624 (77.0%)*

2,455 (92.1%)*

 Combination therapy

556 (20.2%)

507 (26.2%)*

49 (6.1%)*

1,590 (18.2%)

1,380 (23.0%)*

210 (7.9%)*

Medication adherence

 Adherence (N, %)^a

799 (29.1%)

566 (29.3%)

230 (28.8%)

2,763 (31.6%)

2,016 (33.6%)*

740 (27.8%)*

 MPR (Mean, SD)

0.46 (0.37)

0.47 (0.37)

046 (0.37)

0.49 (0.37)

0.51 (0.37)*

0.46 (0.36)*