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Table 1 Patient Characteristics at Index Date

From: Weight gain and comorbidities associated with oral second-generation antipsychotics: analysis of real-world data for patients with schizophrenia or bipolar I disorder

Parameter Patients With SZ
(n = 8174)
Patients With BD-I
(n = 9142)
Sex, n (%)
 Female 5037 (61.6) 6604 (72.2)
Race, n (%)a
 White 5554 (80.9) 7036 (89.7)
 Black 1235 (18.0) 770 (9.8)
 Other 75 (1.1) 37 (0.5)
Age at index, mean (SD), years 57.4 (17.7) 48.2 (15.3)
Age category at index, n (%), years
 18–24 354 (4.3) 634 (6.9)
 25–34 656 (8.0) 1359 (14.9)
 35–44 908 (11.1) 1680 (18.4)
 45–54 1515 (18.5) 2111 (23.1)
 55–64 1788 (21.9) 1942 (21.2)
  ≥ 65 2953 (36.1) 1416 (15.5)
Insurance type, n (%)b
 Commercial 2781 (40.4) 3677 (51.1)
 Medicaid 773 (11.2) 939 (13.1)
 Medicare 2392 (34.7) 1742 (24.2)
 Multiple 909 (13.2) 775 (10.8)
 Other 31 (0.5) 59 (0.8)
Comorbidities, n (%)c
 Depression 4208 (51.5) 4883 (53.4)
 Anxiety disorders 3988 (48.8) 5142 (56.2)
 Chronic pulmonary disease 3597 (44.0) 3943 (43.1)
 Diabetes without chronic complications 2253 (27.6) 1787 (19.5)
 Cerebrovascular disease 1884 (23.0) 1093 (12.0)
 Congestive heart failure 1132 (13.8) 615 (6.7)
 Peripheral vascular disease 1048 (12.8) 623 (6.8)
 Myocardial infarction 592 (7.2) 389 (4.3)
 Current tobacco use 3667 (44.9) 4442 (48.6)
Weight, mean (SD), kg 85.05 (23.5) 87.55 (24.1)
BMI category, n (%)d
  < 18.5 kg/m2 168 (2.1) 142 (1.6)
 18.5–24.9 kg/m2 1968 (24.3) 1924 (21.1)
 25.1–29.9 kg/m2 2277 (28.1) 2425 (26.6)
  ≥ 30.0 kg/m2 3690 (45.5) 4619 (50.7)
SGA treatment, n (%)
 Olanzapine 1513 (18.5) 1564 (17.1)
 Clozapine 236 (2.9) N/A
 Iloperidone 38 (0.5) N/A
 Paliperidone 193 (2.4) N/A
 Risperidone 2246 (27.5) 1633 (17.9)
 Quetiapine 4038 (49.4) 5935 (64.9)
 Olanzapine/fluoxetine combination N/A 69 (0.8)
  1. aTotal n = 6864 for SZ, n = 7843 for BD-I
  2. bTotal n = 6886 for SZ, n = 7192 for BD-I
  3. cThe 3 comorbidities with the highest prevalence for each patient cohort (depression, anxiety disorders, and chronic pulmonary disease) are shown, in addition to select other cardiovascular and diabetes comorbidities
  4. dTotal, n = 8103 for SZ, n = 9110 for BD-I
  5. BD-I, bipolar I disorder; BMI, body mass index; N/A, not applicable; SD, standard deviation; SZ, schizophrenia