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Table 2 Results of all outcomes (individual studies and overall effect)

From: Comparative short-term efficacy and acceptability of a combination of pharmacotherapy and psychotherapy for depressive disorder in children and adolescents: a systematic review and meta-analysis

Studies

Remission

Acceptability

Efficacy at post treatment

Suicidality

Odds ratio (95% CI)

Odds ratio (95% CI)

Standard mean difference (95% CI)

Odds ratio (95% CI)

Bernstein 2000

2.26 (0.75 to 6.82)

0.75 (0.24 to 2.33)

-0.44 (-0.94 to 0.06)

Not reported

Clarke 2005

1.10 (0.58 to 2.11)

1.14 (0.51 to 2.54)

0.08 (-0.28 to 0.43)

Not reported

Cornelius 2009

Not reported

0.14 (0.01 to 2.80)

0.27 (-0.29 to 0.83)

Not estimable

Davey 2019

0.55 (0.16 to 1.92)

Not reported

0.10 (-0.46 to 0.66)

1.82 (0.57 to 5.79)

Deas 2000

0.17 (0.22 to 6.20)

7.86 (0.28 to 217.11)

0.36 (-0.90 to 1.61)

Not reported

Fristad 2019a

8.75 (0.88 to 86.60)

0.39 (0.02 to 9.03)

0.09 (-0.76 to 0.94)

Not reported

Fristad 2019b

1.17 (0.22 to 6.20)

0.65 (0.02 to 17.51)

0.00 (-0.80 to 0.80)

Not reported

Goodyer 2008

Not reported

1.89 (0.67 to 5.32)

0.19 (-0.09 to 0.47)

0.85 (0.30 to 2.43)

Gunlicks-Stoessel 2019

Not reported

0.80 (0.08 to 8.47)

0.24 (-0.86 to 1.33)

Not estimable

Iftene F 2015a

0.65 (0.18 to 2.29)

0.93 (0.16 to 5.50)

0.38 (-0.25 to 1.01)

Not estimable

Iftene F 2015b

0.55 (0.14 to 2.13)

0.84 (0.14 to 5.01)

0.11 (-0.54 to 0.77)

Not estimable

Kim 2012

Not reported

0.77 (0.16 to 3.73)

-0.53 (-1.02 to -0.03)

Not reported

Mandoki 1997

Not reported

1.42 (0.27 to 7.34)

0.73 (0.09 to 1.38)

Not reported

March 2004a

3.04 (1.44 to 6.42)

0.63 (0.26 to 1.51)

-1.22 (-1.57 to -0.87)

1.25 (0.29 to 5.42)

March 2004b

2.04 (1.00 to 4.15)

0.77 (0.30 to 1.97)

-0.61 (-0.95 to -0.28)

0.67 (0.17 to 2.57)

Melvin 2006a

0.62 (0.10 to 3.76)

6.30 (0.58 to 68.42)

0.34 (-0.35 to 1.03)

5.40 (0.20 to 142.71)

Melvin 2006b

0.84 (0.14 to 5.10)

0.84 (0.14 to 5.10)

-0.02 (-0.70 to 0.66)

0.50 (0.05 to 5.03)

Riggs 2007

2.11 (1.01 to 4.37)

1.27 (0.49 to 3.31)

-0.33 (-0.68 to 0.02)

4.20 (0.46 to 38.71)

Total

    

Overall effect

1.37 (0.93 to 2.04)

0.99 (0.72 to 1.38)

-0.07 (-0.32 to 0.19)

1.17 (0.67 to 2.06)

P for overall effect

0.11

0.98

0.60

0.58

I2

36%

0%

76%

0%

P for heterogeneity

0.10

0.88

< 0.00001

0.65

Statistical power

93%

5%

6%

16%

  1. CI confidence interval; P level of significance; I2 measure of heterogeneity