Fig. 2

Brain activity in response to 33 ms aversive (vs. neutral) cues, correlated with total childhood abuse scores (TCAs). A Brain images showing a significant relationship of brain response to aversive cues with TCAs in the ventral medial orbitofrontal cortex (mOFC), including nodes in the subgenual anterior cingulate cortex (sgACC) and the medial frontal gyrus (MFG). Images shown at 2.4 to 4 for visualization purposes. B Scatterplot of the mean beta values extracted from the significant relationship in (A) plotted as a function of TCAs (log-transformed due to non-normal distribution). r² value of this relationship was 0.32 (used as the baseline for multiple regression and testing of moderating variables [see Table 3])