Characteristics of platelet-associated parameters and their predictive values in Chinese patients with affective disorders

Table 5 Comparison of sociodemographic and laboratory variables between the MDD group with the BD manic episodes group or with the BD depressive episodes group

Variables	MDD group (n = 8899)	BD depressive episodes group (n = 1664)	BD manic episodes group (n = 3444)	t/F/²	P	P1	P2	P3	P4	P5	P6
Age(year)	44.95 ± 0.193^ab	39.35 ± 0.385	39.11 ± 0.260	181.395	0.000	0.000	0.000	0.000	0.000	0.640	1.000
Sex (male/female)	3193/5709^ab	836/828	1815/1629	345.263	0.000	0.000	0.000	0.000	0.000	0.099	0.297
Platelet	239.662 ± 0.665^a	234.326 ± 1.544	238.354 ± 1.096^a	4.260	0.014	0.004	0.011	0.764	1.000	0.016	0.048
MPV	9.392 ± 0.011^ab	9.512 ± 0.027	9.650 ± 0.019^a	57.513	0.000	0.001	0.003	0.000	0.000	0.000	0.000
PDW	13.764 ± 0.025	13.851 ± 0.058	13.863 ± 0.041	1.975	0.139	0.237	0.711	0.068	0.204	0.854	1.000
PCT	0.208 ± 0.001^b	0.206 ± 0.001	0.214 ± 0.001^a	17.759	0.000	0.196	0.589	0.000	0.000	0.000	0.000
Neutrophil	3.367 ± 0.015^ab	3.670 ± 0.039	3.962 ± 0.031^a	145.385	0.000	0.000	0.000	0.000	0.000	0.000	0.000
Lymphocyte	1.859 ± 0.006^ab	1.986 ± 0.016	2.012 ± 0.011	31.449	0.000	0.000	0.000	0.000	0.000	0.226	0.678
RDW	13.691 ± 0.018^ab	13.557 ± 0.038	13.474 ± 0.027	15.521	0.000	0.016	0.048	0.000	0.000	0.226	0.678
Albumin	43.168 ± 0.038^b	43.642 ± 0.100	43.303 ± 0.068^a	16.010	0.000	0.787	1.000	0.000	0.000	0.000	0.001
PLR	140.599 ± 0.607^ab	128.612 ± 1.269	130.729 ± 0.965	17.704	0.000	0.000	0.000	0.000	0.000	0.115	0.346
SII	482.126 ± 3.945^b	489.108 ± 9.022	530.295 ± 7.122^a	26.774	0.000	0.132	0.397	0.000	0.000	0.000	0.000
RPR	0.061 ± 0.000	0.062 ± 0.001	0.061 ± 0.000^a	3.874	0.021	0.032	0.096	0.215	0.646	0.005	0.016
PAR	5.578 ± 0.021^a	5.394 ± 0.036	5.530 ± 0.026^a	5.892	0.000	0.006	0.018	0.169	0.507	0.001	0.002

HC Healthy controls, MDD Major depressive disorder, BD Bipolar disorder, MPV Mean platelet volume, PDW Platelet distribution width, PCT Plateletcrit, RDW Red blood cell distribution width, PLR Platelet to lymphocyte ratio, SII Systemic immune-inflammation index, RPR RDW to platelet ratio, PAR Platelet to albumin ratio; a, vs. BD depressive episodes group, P < 0.05; b, vs. BD manic episodes, P < 0.05, p values after correction. P, comparison among MDD group, BD depressive episodes group and BD manic episodes group; P1, MDD group vs BD depressive episodes group, p values uncorrected; P2, MDD group vs BD depressive episodes group, p values after correction; P3, MDD group vs BD manic episodes group, p values uncorrected; P4, MDD group vs BD manic episodes group, p values after correction; P5, BD depressive episodes group vs BD manic episodes group, p values uncorrected; P6, BD depressive episodes group vs BD manic episodes group, p values after correction. Values are represented as mean ± SEM

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