The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients

BMC Psychiatry

Table 1 Main demographic characteristics of the patients

	All	Women	Men	Non-AUD	AUD
n1	242	148	94	143	99
n2	148	93	55	101	47
Drop-out rate	−39%	−37%	−41%	−29%	−53%
Age, years (range)	38.8 (17–64)	38.1 (17–64)	39.9 (18–64)	38.7 (17–64)	38.9 (18–62)
MADRS, baseline (SD)	23.16 (6.70)	22.26^a (6.79)	24.52 (6.37)	22.83^b (6.73)	23.65 (6.67)
MADRS, 6 months (SD)	13.26 (8.72)	11.72^c (8.23)	15.85 (9.00)	12.87^d (8.69)	14.09 (8.83)
Effect of treatment in MADRS score	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001
Alcohol doses /week, mean (SD)	10.1 (22.8)	5.5 (9.2)	16.9 (32.9)	1.9 (3.9)	20.4 (31.2)
Median (IQR)	1.0 (12.0)	1.0 (8.0)	25 (19.0)	0 (2.0)	12.0 (25.0)
BMI, baseline (SD)	28.22 (6.67)	28.49 (7.39)	27.80 (14.36)	28.46 (7.08)	27.86 (6.03)
BMI, 6 months (SD)	28.89 (6.74)	29.01 (7.60)	28.71 (5.19)	28.81 (7.27)	29.07 (5.53)
Cigarettes per day (SD)	8.30 (9.61)	6.49 (6.49)	11.26 (11.26)	5.38 (8.25)	12.78 (9.88)
n3	206	120	86	130	76
Flxeqv/mg per day (SD)	28.0 (20.6)	25.0 (18.6)	32.7 (21.3)	26.0 (18.9)	30.9 (22.5)
n4	66	33	33	27	39
Cpzeqv/mg per day (SD)	111.1 (129.3)	108.8 (140.0)	119.8 (113.4)	91.2 (90.0)	124.8 (150.3)

n1, number of patients at baseline; n2, number of patients at 6 months; n3, number of patients with anti-depressant medication; n4, number of patients with anti-psychotic medication.
Flxeqv, fluoxetine equivalent dose; Cpzeqv, chlorpromazine equivalent dose
Drop-out rate including patients with full symptom recovery and treatment conclusion before 6-month follow-up. Significance of difference in drop-out rate between study groups assessed with Pearsons Chi-Square test (χ² = 14.04, df = 2, p = 0.001).
^a Mean difference in MADRS score between men and women at baseline p < 0.05; ^b Mean difference in MADRS score between AUD and non-AUD groups at baseline p = ns; ^c Mean difference in MADRS score between men and women at 6 months p < 0.01; ^d Mean difference in MADRS score between AUD and non-AUD groups at 6 months p = ns

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