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Fig. 2 | BMC Psychiatry

Fig. 2

From: Optimal dose determination of enerisant (TS-091) for patients with narcolepsy: two randomized, double-blind, placebo-controlled trials

Fig. 2

Simulation of H3 receptor occupancy after enerisant administration. The time-course of histamine H3 receptor occupancy after a single oral administration of enerisant was simulated, and the time to maintain 90% of H3 receptor occupancy was calculated. In the simulation, pharmacokinetic data obtained from the enerisant single ascending dose study and the pharmacodynamics data obtained from the H3 receptor occupancy study of enerisant [9] were used. Phoenix WinNonlin (ver.6.2) and Microsoft Excel 2010 were used as the analysis software

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BMC Psychiatry

ISSN: 1471-244X

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