Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study

BMC Psychiatry

Table 2 Brain areas with significantly different FC among the SD, NSD, and HC groups using the left vAI as the seed region

Brain regions	MNI (x y z)	Cluster size	F/t -value
Three groups
Rectus_L	-6 48–18	9	11.258^a
Rectus_R	9 45–18	11	11.135^a
Fusiform_R	24–30 -18	10	12.893^a
Inferior frontal orbital gyrus_R	48 39–6	23	11.666^a
Angular_R	63–51 27	9	8.885^a
SD vs NSD
Rectus_R	9 45–18	10	−4.513^b
Fusiform_R	24–30 -18	10	-5.146^b
Angular_R	60–51 24	9	-4.341^b
SD vs HC
Fusiform_R	24–30 -21	4	-4.493^b
NSD vs HC
Rectus_L	−6 48–18	6	4.002^b
Rectus_R	3 42–21	9	4.227^b
Inferior frontal orbital gyrus_R	48 39–9	20	4.575^b

SD Somatic depression, NSD Non-somatic depression, HC Healthy control, vAI ventral anterior insula, MNI Montreal Neurological Institute, x, y, z are the coordinates of the primary peak locations in the MNI space; F is obtained by one-way analysis of variance; t is obtained by two-sample two-tailed t test (p < 0.05, alphasim correction), L Left, R Right
^aThe F statistical value
^bThe t statistical value

ISSN: 1471-244X