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Table 3 Brain areas with significantly different FC among the SD, NSD, and HC groups using the right vAI as the seed region

From: Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study

Brain regions MNI (x y z) Cluster size F/t -value
Three groups
 Superior frontal orbital gyrus_R 15 36–21 6 9.581a
 Inferior frontal orbital gyrus_L −36 18–18 7 9.403a
 Superior frontal gyrus_R 21 27 54 7 8.568a
 Middle cingulate gyrus_R 9–39 33 20 11.745a
 Posterior cingulate gyrus_L −6 − 42 24 7 11.388a
 Precuneus_R 9–63 24 9 9.456a
SD vs NSD
 Middle cingulate gyrus_R 9–39 33 16 −4.657b
 Precuneus_R 9–63 24 9 − 4.483b
 Superior frontal gyrus_R 21 27 54 7 -4.190b
SD vs HC
 Posterior cingulate gyrus_L −6 − 42 24 7 −4.717b
 Precuneus_R 12–39 39 16 -4.722b
NSD vs HC
 Superior frontal orbital gyrus_R 18 36–21 6 3.852b
 Inferior frontal orbital gyrus_L −33 21–18 3 3.588b
  1. SD Somatic depression, NSD Non-somatic depression, HC Healthy control, vAI Ventral anterior insula, MNI Montreal Neurological Institute, x, y, z are the coordinates of the primary peak locations in the MNI space; F is obtained by one-way analysis of variance; t is obtained by two-sample two-tailed t test (p < 0.05, alphasim correction); L left, R Right
  2. aThe F statistical value
  3. bThe t statistical value