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Table 1 Participant Characteristics at Baseline and Follow-up (SEBAS 2000 and SEBAS 2006)

From: Loneliness and isolated living status in middle-aged and older adults in Taiwan: exploration on stress-related biomarkers, depressive symptoms, and disability

Variable

SEBAS2000

SEBAS2006

Paired t or χ2

P

Age (years, mean ± SD)

66.0±7.3

72.0±7.2

-203.27

<0.001

Sex (Male/Female)

370/259

370/259

-

-

Marital status (n/%)

  

34.3

<0.001

  Unmarried

139(22.1)

180(28.6)

 

  Married

490(77.9)

449(71.4)

 

Living alone (n/%)

  

10.8

0.001

  Yes

36(5.7)

57(9.1)

 

  No

593(94.3)

572(90.9)

 

Loneliness

  

0.13

0.72

 Yes

91 (14.4)

87 (13.8)

  

 No

538 (85.6)

542 (86.2)

  

Education (n/%)

  

-

-

 No schooling

162 (25.8)

162 (25.8)

  

 Elementary (<6 yrs)

 Junior High (7-9 yrs)

 Senior High (9-12 yrs)

 College (>12 yrs)

278 (44.2)

68 (10.8)

69 (11.0)

52 (8.2)

278 (44.2)

68 (10.8)

69 (11.0)

52 (8.2)

  

Health status (n/%)

High blood pressure

  

56.9

<0.001

 Yes

174 (27.7)

259 (41.2)

  

 No

455 (72.3)

370 (58.8)

  

Diabetes

  

44.6

<0.001

 Yes

76 (12.1)

126 (20.0)

  

 No

553 (87.9)

503 (80.0)

  

Heart disease

  

26.0

<0.001

 Yes

85 (13.5)

142 (22.6)

  

 No

544 (86.4)

487 (77.4)

  

Stroke

  

24.1

<0.001

 Yes

8 (1.3)

34 (5.4)

  

 No

621 (98.7)

595 (94.6)

  

Cancer/malignant tumor

  

2.6

0.10

 Yes

4 (0.6)

10 (1.6)

  

 No

625 (99.4)

619 (98.4)

  

Lower respiratory disease

  

0.06

0.80

 Yes

48 (7.6)

50 (8.0)

  

 No

581 (92.4)

579 (92.0)

  

Arthritis/rheumatism

  

3.6

0.06

 Yes

97 (15.4)

118 (18.8)

  

 No

532 (84.6)

511 (81.2)

  

Liver/gall bladder disease

  

6.5

0.01

 Yes

23 (3.7)

41 (6.5)

  

 No

606 (96.3)

588 (93.5)

  

Kidney disease

  

3.2

0.07

 Yes

27 (4.3)

40 (6.4)

  

 No

602 (95.7)

589 (93.6)

  

Perceived Stress Scale

-

9.1±6.4

-

-

Stress-related biomarkers

Cortisol levels

19.7±18.3

12.1±17.2

7.64

<0.001

 IL-6 levels

2.9±3.3

4.0±6.0

-4.06

<0.001

 hsCRP

-

0.3±0.6

-

-

Depression (CES-D)#

Disability

4.7±4.8

4.9±5.2

-0.87

0.39

  Motility

2.7±4.2

5.1±6.2

-11.8

<0.001

  IADLs

0.6±1.8

2.0±3.6

-10.8

<0.001

  1. Note. Numbers are Mean±SD or N (%). CES-D The Center for Epidemiologic Studies Depression Scale; IADLs Instrumental Activities of Daily Living; IL-6 Interleukin-6; hsCRP High sensitivity C-reactive protein. #9-item CES-D score (excluding lonely). *p < 0.05; **p < 0.01; *** p < 0.001