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Fig. 2 | BMC Psychiatry

Fig. 2

From: BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model

Fig. 2

Effects of (2R,6R)-HNK on chronic restraint stress (CRS)-induced depression-like behaviors. A-C Histograms showing the total distance traveled, time spent in the center, and number of entries into the center of the open field by mice during the open field test. D Histogram showing the immobility time of the mice in the forced swimming test (FST). E-G Histograms showing weight loss during the fast for the novelty suppressed feeding test (NSFT), the feeding latency, and the total food consumption in the NSFT. H Histogram showing the immobility time of the mice in the tail suspension test (TST). Data are presented as the mean ± SEM (n = 16 mice per group). *P < 0.05, **P < 0.01, and ***P < 0.001. N.S., not significant

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