Table 4 Mediation Analysis for social support on the association between opioid misuse and suicide attempt
Residency | Opioid Misuse | Social Support | Prevalence of Suicide Attempt (%) | Controlled Direct Effect (CDE): Due Neither to Mediation nor Interaction | Reference Interaction (INTref): Due to Interaction Only | Mediated Interaction (INTmed): Due to Mediation and Interaction | Pure Indirect Effect (PIE): Due to Mediation Only |
|---|---|---|---|---|---|---|---|
Percent (95% CI) P-value | Percent (95% CI) P-value | Percent (95% CI) P-value | Percent (95% CI) P-value | ||||
Overall | Yes | low SS | 50.12 | 53.77 (51.01-56.54) p < 0.0001 | 41.05 (38.64-43.46) p < 0.0001 | −18.46 (−19.97--16.95) p < 0.0001 | 23.64 (21.68-25.60) p < 0.0001 |
Moderate SS | 38.65 | ||||||
High SS | 23.42 | ||||||
No | low SS | 18.04 | |||||
Moderate SS | 11.45 | ||||||
High SS | 7.42 | ||||||
Rural on reservation | Yes | low SS | 49.1 | 72.38 (66.14-78.63) p < 0.0001 | 24.12 (18.69-29.56) p < 0.0001 | −13.20 (−16.56- -9.83) p < 0.0001 | 16.69 (12.38-21.00) p < 0.0001 |
Moderate SS | 34.01 | ||||||
High SS | 30.25 | ||||||
No | low SS | 17.31 | |||||
Moderate SS | 10.37 | ||||||
High SS | 7.73 | ||||||
Rural off reservation | Yes | low SS | 51.44 | 43.43 (39.83-47.02) p < 0.0001 | 49.52 (46.47-52.57) p < 0.0001 | −21.25 (−23.43- -19.06) p < 0.0001 | 28.30 (25.33-31.27) p < 0.0001 |
Moderate SS | 35.14 | ||||||
High SS | 20.93 | ||||||
No | low SS | 20.01 | |||||
Moderate SS | 12.53 | ||||||
High SS | 6.55 | ||||||
Urban off reservation | Yes | low SS | 46.79 | 60.36 (54.50-66.21) p < 0.0001 | 36.30 (30.95-41.66) p < 0.0001 | −15.88 (−18.68- -13.08) p < 0.0001 | 19.22 (15.79-22.65) p < 0.0001 |
Moderate SS | 46.5 | ||||||
High SS | 25.66 | ||||||
No | low SS | 15.6 | |||||
Moderate SS | 9.5 | ||||||
High SS | 8.17 |