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Table 2 Characteristics of patients newly initiated on paliperidone palmitate and risperidone microsphere

From: Assessment of risk factors of treatment discontinuation among patients on paliperidone palmitate and risperidone microspheres in France, Germany and Belgium

 

Total

France

Germany

Belgium

Total

25,361 (100%)

9,720 (100%)

14,461 (100%)

1,180 (100%)

Gender

 Women

10,014 (39%)

3,472 (36%)

6,022 (42%)

520 (44%)

 Men

15,347 (61%)

6,248 (64%)

8,439 (58%)

660 (56%)

Age

 18–30 years

4,687 (18%)

2,236 (23%)

2,451 (17%)

-

 31–50 years

11,348 (45%)

4,906 (50%)

6,442 (45%)

-

 > 50 years

8,146 (32%)

2,578 (27%)

5,568 (39%)

-

Type of treatment

 Paliperidone palmitate

18,028 (71%)

7,463 (77%)

9,756 (67%)

809 (69%)

 Risperidone microspheres

7,333 (29%)

2,257 (23%)

4,705 (33%)

371 (31%)

Previous treatment

 Other LAT

4,658 (18%)

1,807 (19%)

2,736 (19%)

115 (10%)

 Oral AP

9,456 (37%)

2,902 (30%)

6,146 (43%)

408 (35%)

 No AP

11,247 (44%)

5,011 (52%)

5,579 (39%)

657 (56%)

Average dosage per 30 daysa

 < 75 mg

5,000 (20%)

1,787 (18%)

2,889 (20%)

324 (27%)

 75–125 mg

13,208 (52%)

4,708 (48%)

7,968 (55%)

532 (45%)

 > 125 mg

7,153 (28%)

3,225 (33%)

3,604 (25%)

324 (27%)

Combination therapy

 Monotherapy

12,480 (49%)

5,574 (57%)

6,252 (43%)

654 (55%)

 Combination therapy

12,881 (51%)

4,146 (43%)

8,209 (57%)

526 (45%)

Specialty of the prescribers

 GP only

1,867 (7%)

622 (6%)

831 (6%)

414 (35%)

 Psychiatrist + GP

2,736 (11%)

1,074 (11%)

1,310 (9%)

352 (30%)

 Psychiatrist only

19,492 (77%)

7,485 (77%)

11,634 (80%)

373 (32%)

 Other

1,266 (5%)

539 (6%)

686 (5%)

41 (3%)

Other treatmentsb

 None

6,676 (26%)

1,220 (13%)

5,267 (36%)

189 (16%)

 1 molecule

3,612 (14%)

1,128 (12%)

2,292 (16%)

192 (16%)

 2 molecules

3,167 (12%)

1,193 (12%)

1,778 (12%)

196 (17%)

 > 2 molecules

11,906 (47%)

6,179 (64%)

5,124 (35%)

603 (51%)

  1. aThe recommended monthly dose of the three study drugs was similar per SmPC (50 mg per 30 days), i.e. risperidone microspheres for 25 mg every two weeks, PP1M for 50 mg per month and PP3M for 175 mg per three months
  2. bBased on the number of distinct molecules other than antipsychotics purchased, patients were classified into four groups: patients who purchased 0, 1, 2 and more than 2 distinct other molecules during the first three months after index