| Univariate | Multivariate (including Belgian data) | Multivariate (excluding Belgian data) | |||||
---|---|---|---|---|---|---|---|---|
Variable | Reference | Class | HR | P value^ | HR | P value^ | HR | P value^ |
Gender | Men | Women | 1.07 |  < .0001 | 1.05 | 0.001 | 1.05 | 0.002 |
Agea | 18–30 years | 31–50 years | 0.96 | 0.051 | - | - | 0.95 | 0.006 |
 |  |  > 50 years | 0.97 | 0.20 | - | - | 0.91 |  < .0001 |
Type of treatment | Paliperidone palmitate | Risperidone microsphere | 2.08 |  < .0001 | 1.96 |  < .0001 | 1.97 |  < .0001 |
Previous treatment | Other LAT | Oral AP | 1.39 |  < .0001 | 1.22 |  < .0001 | 1.22 |  < .0001 |
 |  | No AP | 1.36 |  < .0001 | 1.22 |  < .0001 | 1.21 |  < .0001 |
Dosage per 30 daysb |  < 75 mg | 75–125 mg | 0.94 | 0.003 | 0.98 | 0.36 | 0.98 | 0.27 |
 |  |  > 125 mg | 0.81 |  < .0001 | 0.95 | 0.018 | 0.95 | 0.037 |
Combination therapy | Monotherapy | Combination therapy | 1.05 | 0.003 | 1.05 | 0.001 | 1.06 | 0.001 |
Specialty of the prescribers | Psychiatrist only | GP only | 1.68 |  < .0001 | 1.37 |  < .0001 | 1.36 |  < .0001 |
 |  | Psychiatrist + GP | 0.81 |  < .0001 | 0.76 |  < .0001 | 0.78 |  < .0001 |
 |  | Other | 0.82 |  < .0001 | 0.82 |  < .0001 | 0.81 |  < .0001 |
Other treatmentsc | None | 1 molecule | 1.04 | 0.11 | 1.02 | 0.46 | 1.01 | 0.63 |
 |  | 2 molecules | 1.03 | 0.23 | 0.98 | 0.47 | 0.98 | 0.53 |
 |  |  > 2 molecules | 1.05 | 0.008 | 0.99 | 0.77 | 1.00 | 0.85 |