Table 1 Baseline variables collected to characterize sample

Socio-Demographics

Socio-demographic questionnaire

Self-reported gender, race/ethnicity, age, occupation, number of years of education, marital and work status

Characterization of the sample and variables included in predictive model

Diagnosis

SCID-5, MADRS, YMRS

Diagnosis of BD I or II; list of depressive or manic symptoms

Confirmation of diagnosis and characterization of polarity upon entry to the study

Clinical Course

Clinical questionnaire

Age at onset, number and type of previous episodes, history of suicide attempts, history of psychotic symptoms during episodes, co-morbid disorders, number of lifetime admissions, family history of any psychiatric disorder in first-and second-degree relatives, pattern of mood reactivity (history of antidepressant-induced (hypo)manias, rapid cycling)

Characterization of course of illness (episodic with or without residual symptoms, chronic fluctuating and chronic) and calculation of illness burden index, and variables included in predictive model

Cardiovascular screening

Clinical questionnaire, DASI

BMI, smoking history, presence of kidney disease, family history of angina or myocardial infarction in a first-degree relative before the age of 60

Characterization of the sample

Chronotype

MEQ-19

Morning, intermediate, or evening chronotype

Characterization of the sample and variables included in predictive model

Pharmacotherapy

Clinical questionnaire

Name, dosage, and date medication(s) started

Characterization of the sample and variables included in predictive model