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Table 1 Change in YMRS, HDRS, and CDRS scores over time (N = 26)

From: Findings from a pilot open-label trial of N-acetylcysteine for the treatment of pediatric mania and hypomania

  Baseline Endpoint† Difference Cohen’s d
(95% CI)
Test Statistic P-Value
Mean ± SD Mean ± SD Mean ± SD
YMRS 23.8 ± 5.7 15.7 ± 10.1 -8.1 ± 8.5 0.99 (0.41, 1.56) z = -7.19  < .001
HDRS 15.3 ± 7.9 9.5 ± 8.5 -5.8 ± 7.2 0.70 (0.14, 1.26) z = -3.95  < .001
CDRS 37.1 ± 11.7 31.9 ± 14.7 -5.2 ± 10.7 0.39 (-0.16, 0.94) z = -3.90  < .001
  1. Endpoint mean uses last observation carried forward for subjects who dropped prior to week 12