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Table 2 Summary of studies including sample type, definition employed to describe DP, type of digital technology used, and dimension of depression assessed

From: Exploring the digital footprint of depression: a PRISMA systematic literature review of the empirical evidence

N

N / ref

First Author

Year

Clinical Sample

Definition

Digital technology / Type of data (active and/or passive)

Dimensions of depression

1

[1]

Abela

2007

No

ESM*

Handheld computer (A) #

Mood, cognitive style

2

[2]

Adams

2009

No

ESM*

Handheld computer (A) #

Mood, cognitive style

3

[6]

Bai

2021

Yes

DP*

Mobile app, Wrist sensor, GPS, Accelerometer, Smartphone comm logs, Screen activity (A/P)

Mood, psychomotor activity, sleep

4

[8]

Bartels

2020

No

ESM*

Handheld computer (A) #

Mood, social functioning, depression risk and protective factors (intervention)

5

[12]

Ben-Zeev

2009

Yes

ESM

Handheld computer (A) #

Mood

6

[13]

Ben-Zeev

2015

No

EMA*

Mobile app, GPS, Wi-Fi, Accelerometer, Audio recording, Ambient light (A/P)

Psychomotor activity, sleep, social functioning

7

[15]

Beute

2018

No

EMA

Mobile app (A) #

Mood, depression risk and protective factors (psychosomatic complains)

8

[16]

Bickham

2015

No

EMA*

Handheld computer (A) #

Depression risk and protective factors (media use)

9

[18]

Bos

2019

No

ESM*

Handheld computer (A) #

Mood

10

[21]

Bower

2010

Yes

ESM*

Handheld computer (A) #

Mood, sleep

11

[23]

Brose

2017

No

ESM*

Mobile app (A) #

Depression risk and protective factors (stress)

12

[24]

Brown

2011

No

ESM

Handheld computer (A) #

Mood, social functioning, cognitive performance

13

[25]

Burns

2011

No

EMA

Mobile app, GPS, Wi-Fi, Accelerometer, Smartphone comm logs, Ambient light (A/P)

Depression risk and protective factors (intervention)

14

[27]

Bylsma

2011

No

ESM

Handheld computer (A) #

Mood, social functioning

15

[29]

Cho

2019

Yes

DP

Mobile app, Wrist sensor, Accelerometer (A/P)

Mood, psychomotor activity, sleep

16

[30]

Chow

2017

No

ESM*, Mobile Sensing*

Mobile app, GPS (A/P)

Mood, psychomotor activity, social functioning

17

[31]

Chue

2017

No

EMA*

Handheld computer (A) #

Mood, social functioning

18

[33]

Clasen

2015

No

ESM*

Mobile app (A) #

Mood, cognitive style

19

[35]

Colombo

2020

No

EMA*

Mobile app (A) #

Mood

20

[37]

Cormack

2019

Yes

DP*

Mobile app, Wrist sensor, Accelerometer (A/P)

Mood, psychomotor activity, cognitive performance

21

[40]

Cushing

2018

No

EMA*

Mobile app, Accelerometer (A/P)

Mood, psychomotor activity

22

[45]

Dejonckheere

2019

No

ESM*

Mobile app (A) #

Mood, cognitive style

23

[46]

Demiralp

2012

Yes

ESM*

Handheld computer (A) #

Mood

24

[47]

Depp

2015

Yes

EMA

Mobile app (A) #

Depression risk and protective factors (intervention)

25

[49]

Di Matteo

2020

No

EMA

Mobile app, Smartphone comm logs (A/P)

Psychomotor activity, sleep, social functioning

26

[50]

Di Matteo

2021

No

Passive sensing*

Mobile app, Audio recordings (A/P)

Mood

27

[51]

Dietvorst

2021

No

ESM*

Mobile app, Online survey (A/P)

Mood

28

[52]

Difrancesco

2018

Yes

EMA*, AA*

Mobile app, Wrist sensor, Accelerometer (A/P)

Sleep, psychomotor activity

29

[53]

Eddington

2017

Yes

AA*

Mobile app (A) #

Depression risk and protective factors (intervention)

30

[56]

Elovainio

2020

No

EMA

Mobile app, Accelerometer, Online survey (A/P)

Sleep

31

[58]

Fang

2019

No

ESM

Mobile app (A) #

Cognitive style

32

[59]

Feiler

2005

Yes

Time series analysis

Handheld computer (A) #

Depression risk and protective factors (pain)

33

[65]

Gansner

2020

Yes

EMA

Mobile app (A/P)

Depression risk and protective factors (rheumatoid arthritis and pain)

34

[66]

Geyer

2018

No

EMA

Mobile app (A) #

Mood, social functioning

35

[67]

Giesbrecht

2012

No

EMA*

Handheld computer (A) #

Mood

36

[69]

Goldschmidt

2014

No

EMA

Handheld computer (A) #

Food intake

37

[71]

Graham-Engeland

2016

Yes

EMA

Handheld computer (A) #

Mood, depression risk and protective factors (rheumatoid arthritis and pain)

38

[72]

Gruber

2013

Yes

ESM

Handheld computer (A) #

Mood

39

[73]

Hahn

2021

No

DP*

Online survey (A) #

Mood

40

[74]

Hallensleben

2017

Yes

EMA

Mobile app (A) #

Suicidality

41

[76]

Hamilton

2020

No

EMA*

Mobile app (A) #

Sleep, depression risk and protective factors (social media use)

42

[77]

Hartmann

2015

Yes

ESM

Handheld computer (A) #

Mood, depression risk and protective factors (intervention)

43

[79]

Heninga

2019

Yes

ESM*

Mobile app (A) #

Mood, social functioning, psychomotor activity

44

[80]

Hepp

2019

Yes

AA

Handheld computer (A) #

Mood, social functioning

45

[82]

Hershenberg

2017

Yes

ESM*

Interactive voice recording (A) #

Mood, cognitive style

46

[83]

Holmes

2016

Yes

Time series analysis

Mobile app, Online survey (A) #

Depression risk and protective factors (intervention)

47

[85]

Huckins

2020

No

EMA

Mobile app, GPS, Accelerometer, Screen activity, Ambient light (A/P)

Depression risk and protective factors (COVID-19)

48

[86]

Huffziger (a)

2013

Yes

AA*

Handheld computer (A) #

Mood, cognitive style

49

[87]

Huffziger (b)

2013

No

AA*

Handheld computer (A) #

Mood, cognitive style

50

[88]

Hung

2016

Yes

EMA*

Mobile app (A) #

Mood, sleep, cognitive performance

51

[89]

Husky

2009

No

ESM*

Handheld computer (A) #

Mood

52

[91]

Jacobson (a)

2019

Yes

Digital biomarkers*

Wrist sensor, Accelerometer (P)

Psychomotor activity

53

[92]

Jacobson (b)

2019

Yes

DP*

Wrist sensor, Accelerometer, Ambient light (P)

Psychomotor activity

54

[93]

Jacobson (a)

2020

No

DP*

Mobile app, Accelerometer, Smartphone comm logs (A/P)

Social functioning, psychomotor activity

55

[94]

Jacobson (b)

2020

No

DP*, Passive sensing*

Mobile app, GPS, Wi-Fi, Smartphone comm logs, Ambient light (A/P)

Mood, social functioning, psychomotor activity

56

[97]

Jean

2013

Yes

EMA*

Handheld computer (A) #

Depression risk and protective factors (dep risk following stroke)

57

[100]

Kaufmann

2016

Yes

EMA

Mobile app (A) #

Mood, sleep

58

[102]

Khazanov

2019

Yes

EMA*

Handheld computer (A) #

Mood, cognitive style

59

[103]

Kim

2013

No

EMA

Handheld computer, Wrist sensor, Accelerometer (A/P)

Mood, psychomotor activity

60

[104]

Kim

2014

Yes

EMA*

Handheld computer, Wrist sensor, Accelerometer (A/P)

Mood, psychomotor activity

61

[105]

Kim

2019

No

EMA

Handheld computer, Wrist sensor, Accelerometer (A/P)

Mood, psychomotor activity, sleep

62

[106]

Kircanski

2015

No

ESM*

Handheld computer (A) #

Cognitive style

63

[109]

Koval

2013

No

ESM*

Handheld computer (A) #

Mood

64

[110]

Kramer

2014

Yes

EMA*, ESM

Handheld computer (A) #

Depression risk and protective factors (intervention)

65

[114]

Lavender

2013

Yes

EMA*

Handheld computer (A) #

Mood, food intake

66

[121]

Maher

2018

No

EMA

Mobile app (A) #

Mood

67

[122]

Mak

2020

Yes

EMA*

Handheld computer (A) #

Mood, dep risk and protective factors (rheumatoid disease and pain)

68

[125]

Mata

2012

Yes

ESM*

Handheld computer (A) #

Mood, psychomotor activity

69

[126]

McIntyre

2021

Yes

EMA

Mobile app, GPS, Smartphone comm logs (A/P)

Psychomotor activity, social functioning

70

[128]

Melcher

2021

No

DP

Mobile app, GPS, Accelerometer (A/P)

Psychomotor activity, sleep

71

[130]

Minaeva (a)

2020

Yes

ESM, AA*

Mobile app, Accelerometer (A/P)

Mood, psychomotor activity, sleep

72

[131]

Minaeva (b)

2020

No

EMA*, AA*

Wrist sensor, Accelerometer (P)

Mood, psychomotor activity

73

[134]

Moreno

2012

No

ESM

Mobile app, Online survey (A) #

Depression risk and protective factors (Internet use)

74

[135]

Moshe

2021

No

DP

Mobile app, Ring, GPS, Accelerometer, Smartphone comm logs, Screen activity (A/P)

Mood, psychomotor activity, sleep

75

[136]

Moukaddam

2019

Yes

DP*, EMA

Mobile app, GPS, Accelerometer, Smartphone comm logs, Screen activity, Ambient light (A/P)

Mood, social functioning, sleep

76

[138]

Narziev

2020

No

EMA*, Passive sensing

Mobile app, Wrist sensor, Accelerometer, Smartphone comm logs, Screen activity, Ambient light (A/P)

Mood, psychomotor activity, social functioning, sleep

77

[139]

Nelson

2018

Yes

EMA*

Mobile app (A) #

Mood

78

[141]

Nook

2021

No

ESM

Mobile app (A) #

Mood

79

[142]

Nylocks

2019

Yes

ESM*

Handheld computer (A) #

Mood, psychomotor activity

80

[143]

Odgers

2017

Yes

EMA*

Mobile app (A) #

Depression risk and protective factors (exposure to violence)

81

[144]

O’Leary

2017

Yes

ESM

Handheld computer (A) #

Mood, sleep

82

[147]

Panaite

2018

Yes

EMA*

Mobile app, Voice recording (A) #

Mood

83

[148]

Panaite

2019

No

EMA*

Handheld computer (A) #

Mood, cognitive style

84

[150]

Pasyugina

2015

No

ESM

Mobile app, Voice recording (A) #

Mood, cognitive style

85

[151]

Pe

2014

No

ESM*

Handheld computer (A) #

Mood

86

[152]

Pedrelli

2020

Yes

DP

Mobile app, Wrist sensor, GPS, Accelerometer, Smartphone comm logs (A/P)

Psychomotor activity, social functioning

87

[153]

Peterson

2020

Yes

EMA*

Mobile app (A) #

Depression risk and protective factors (intervention)

88

[154]

Place

2017

Yes

Mobile sensing

Mobile app, GPS, Wi-Fi, Accelerometer, Smartphone comm logs, Screen activity, Speech technology (A/P)

Psychomotor activity, social functioning

89

[155]

Putnam

2007

Yes

EMA*

Handheld computer (A) #

Cognitive style

90

[157]

Robbins

2011

Yes

EMA*, AA*

Audio recordings (P)

Depression risk and protective factors (rheumatoid arthritis)

91

[158]

Rodriguez

2021

No

ESM

Mobile app (A) #

Depression risk and protective factors (social media use)

92

[183]

Roekel

2016

No

ESM

Mobile app, handheld computer (A) #

Mood

93

[160]

Sagar

2016

Yes

EMA

Handheld computer (A) #

Depression risk and protective factors (marihuana use)

94

[162]

Schultebraucks

2020

Yes

DP*

Speech technology and facial recognition (A/P)

Psychomotor activity

95

[163]

Sears

2018

No

ESM*

Mobile app (A) #

Mood, social functioning

96

[166]

Sheets

2020

Yes

EMA

Handheld computer (A) #

Mood

97

[167]

Snippe

2016

Yes

ESM*

Handheld computer (A) #

Depression risk and protective factors (intervention)

98

[168]

Sperry

2018

No

ESM*, AA

Mobile app, Handheld computer, Chest patch (A/P)

Psychomotor activity, social functioning, food intake

99

[170]

Stasak

2019

Yes

DP*

Speech technology and facial recognition (A) #

Psychomotor activity, cognitive performance

100

[171]

Steenkamp

2019

Yes

ESM

Handheld computer (A) #

Depression risk and protective factors (childhood abuse)

101

[172]

Thompson

2015

No

ESM*

Handheld computer (A) #

Mood

102

[173]

Thompson

2016

Yes

ESM*

Handheld computer (A) #

Mood, cognitive style

103

[174]

Thompson

2017

Yes

ESM*

Handheld computer (A) #

Mood

104

[181]

Trull

2008

Yes

EMA

Handheld computer (A) #

Mood

105

[184]

Vansteelandt

2019

Yes

EMA

Handheld computer (A) #

Cognitive style

106

[186]

Verkuil

2015

No

EMA*

Handheld computer, Chest patch (A/P)

Mood, psychomotor activity

107

[187]

Vesel

2020

No

Digital biomarker*

Mobile app, Typing metadata (A/P)

Psychomotor activity, cognitive performance

108

[188]

Vranceanu

2009

No

EMA

Handheld computer (A) #

Mood, social functioning

109

[189]

Wahle

2016

No

Mobile sensing

Mobile app, GPS, Wi-Fi, Accelerometer, Smartphone comm logs (A/P)

Depression risk and protective factors (intervention)

110

[190]

Wang

2021

No

ESM*

Mobile app (A) #

Mood

111

[191]

Wenze

2006

No

ESM*

Handheld computer (A) #

Mood, cognitive style

112

[192]

Wenze

2009

No

ESM*

Handheld computer (A) #

Mood, cognitive style

113

[193]

Wenze

2012

No

ESM*

Handheld computer (A) #

Mood

114

[194]

Wenze

2018

No

EMA

Mobile app (A) #

Mood, social functioning

115

[196]

Worten-Chaudhari

2017

No

EMA*

Mobile app (A) #

Depression risk and protective factors (intervention)

116

[197]

Wu

2016

No

ESM*

Handheld computer (A) #

Cognitive style

117

[198]

Zhang,

2019

No

Digital biomarker*

Speech technology and facial recognition (A) #

Psychomotor activity

118

[200]

Zulueta

2018

Yes

DP

Mobile app, Accelerometer, Typing metadata (A/P)

Psychomotor activity, cognitive performance

  1. * = Studies where methodology is mentioned without definition; # = Studies that exclusively use self-reported/clinical interview of symptoms of MDD to predict or assess the association with self-reported/clinical interview outcomes. EMA Ecological Momentary Assessment, ESM Experience Sampling Method, DP Digital Phenotype/ing, AA Ambulatory Assessment, N/Ref  Study as numbered in the reference list, Smartphone comm logs Call/SMS frequency, timing, and duration, Active/subjective data collection, P Passive/objective data collection, handheld computer this term refers exclusively to portable electronic devices such as a Palm that can be used to collect self-reported information (it should be noted that mobile phones are not considered handheld computers)