| Schizophrenia patients with experience of sleep disturbances N = 88 (1) | Schizophrenia patients without experience of sleep disturbances N = 90 (2) | Schizophrenia patients with experience of anxiety problems N = 66 (3) | Schizophrenia patients without experience of anxiety problems N = 112 (4) | P-value | |||||||||
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Health outcomes (Unadjusted) | n | Mean | SD | n | Mean | SD | n | Mean | SD | n | Mean | SD | (1) vs. (2) | (3) vs. (4) |
HRQoL | ||||||||||||||
 MCS (Japanese norm) | 88 | 43.02 | 11.49 | 90 | 47.91 | 11.11 | 66 | 43.71 | 11.57 | 112 | 46.55 | 11.43 | 0.004 | 0.113 |
 PCS (Japanese norm) | 88 | 44.43 | 15.27 | 90 | 47.95 | 12.55 | 66 | 44.25 | 16.24 | 112 | 47.37 | 12.48 | 0.094 | 0.152 |
 RCS (Japanese norm) | 88 | 29.14 | 16.85 | 90 | 38.56 | 16.99 | 66 | 26.90 | 16.77 | 112 | 38.03 | 16.69 | <  0.001 | <  0.001 |
 EQ-5D index | 88 | 0.65 | 0.21 | 90 | 0.75 | 0.17 | 66 | 0.62 | 0.22 | 112 | 0.75 | 0.16 | <  0.001 | <  0.001 |
 EQ-5D VAS | 88 | 46.64 | 27.36 | 90 | 65.79 | 21.21 | 66 | 44.12 | 28.44 | 112 | 63.51 | 21.92 | <  0.001 | <  0.001 |
WPAI | ||||||||||||||
 Absenteeism % | 46 | 26.11 | 31.10 | 41 | 7.20 | 17.21 | 35 | 21.94 | 23.64 | 52 | 14.00 | 28.97 | 0.001 | 0.181 |
 Presenteeism % | 45 | 53.11 | 33.36 | 43 | 29.77 | 26.95 | 36 | 53.61 | 33.05 | 52 | 33.46 | 29.56 | 0.001 | 0.004 |
 Total work impairment % | 44 | 63.16 | 29.75 | 41 | 32.00 | 28.97 | 35 | 63.66 | 27.98 | 50 | 37.26 | 32.34 | <  0.001 | <  0.001 |
 Total activity impairment % | 88 | 53.30 | 31.32 | 90 | 34.67 | 27.69 | 66 | 55.91 | 31.57 | 112 | 36.79 | 28.32 | <  0.001 | <  0.001 |
PHQ-9 score | 88 | 13.44 | 8.23 | 90 | 7.73 | 7.54 | 66 | 14.73 | 9.02 | 112 | 8.10 | 6.90 | <  0.001 | <  0.001 |
Indirect cost (in thousand yen) | 44 | 2369.98 | 1281.20 | 41 | 1144.09 | 1031.88 | 35 | 2321.00 | 1194.38 | 50 | 1399.03 | 1270.28 | <  0.001 | 0.001 |