Table 2 Characteristics of patients (n = 449) treated with a Long Acting Injection (LAI) drug, divided in on–label and off–label prescription
ON LABEL | OFF LABEL | SIG | |
|---|---|---|---|
Diagnosis | p = 0.000 | ||
SCZ (n = 331) | 331 (100%) | 0 | |
Schizophrenia | 251 (100%) | 0 | |
Schizoaffective disorder | 74 (100%) | 0 | |
Organic Psychosis | 4 (100%) | 0 | |
Substance-related psychosis | 2 (100%) | 0 | |
NO-SCZ (n = 118) | 4 (3.4%) | 114 (96.6%) | |
Bipolar Disorder | 4 (4.9%) | 77 (95.1%) | |
OCD | 0 | 4 (100%) | |
Personality disorder | 0 | 27 (100%) | |
Neurodevelopment disorder | 0 | 4 (100%) | |
Neurocognitive disorder | 0 | 2 (100%) | |
Age* | 40.97 ± 12.65 | 44.11 ± 13.18 | p = 0.0334 |
Previous LAI therapy | p = 0.14 | ||
Yes (n = 135) | 107 (79.3%) | 28 (20.7%) | |
No (n = 314) | 228 (72.6%) | 86 (27.4%) | |
Drug category | p = 0.52 | ||
FGA (n = 135) | 98 (72.6%) | 37 (27.4%) | |
SGA (n = 314) | 237 (75.5%) | 77 (24.5%) | |
Gender | p = 0.044 | ||
Male (n = 272) | 212 (77.9%) | 60 (22.1%) | |
Female (n = 177) | 123 (69.5%) | 54 (30.5%) | |
Alcohol | p = 0.021 | ||
Yes (n = 65) | 41 (63.1%) | 24 (36.9%) | |
No (n = 384) | 294 (76.6%) | 90 (23.4%) | |
Substance Misuse | p = 0.26 | ||
Yes (n = 90) | 63 (70%) | 27 (30%) | |
No (n = 359) | 272 (75.8%) | 87 (24.2%) | |
BPRS total* | 50.45 ± 14.66 | 45.12 ± 14.09 | p = 0.0013 |
BPRS anxiety depression* | 10.44 ± 4.36 | 10.88 ± 4.25 | p = 0.33 |
BPRS anergy* | 9.83 ± 4.27 | 8.01 ± 3.56 | p = 0.0001 |
BPRS thought disturbances* | 12.88 ± 5.37 | 9.91 ± 4.89 | p = 0.0000 |
BPRS activation* | 7.64 ± 3.35 | 7.63 ± 3.35 | p = 0.91 |
BPRS hostility* | 9.68 ± 4.46 | 8.69 ± 4.40 | p = 0.0474 |
Kemp’s 7 total* | 4.81 ± 1.44 | 4.74 ± 1.43 | p = 0.64 |
DAI-10 total* | 1.78 ± 5.39 | 2.57 ± 5.24 | p = 0.15 |