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Table 2 Antipsychotic medication use and mean medication possession ratio of the overall cohort during the pre-index and post-index periods

From: Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study

  Pre-index period
(n = 1,211; 100%)
Post-index period
(n = 1,211; 100%)
Mean difference
[95% CI]
Received ≥ 1 dispensation, n (%)
 Oral
  First generation 130 (10.7%) 120 (9.9%)  
  Second generation 966 (79.8%) 841 (69.5%)  
 Long acting-injectable
  First generation 192 (15.9%) 67 (5.5%)  
  Second generation N/A (N/A) 1,211 (100%)  
Medication possession ratio, mean (SD); mean difference [95%CI]
 Overall 0.45 (0.40) 0.84 (0.26) 0.39 [0.36, 0.41]
  Oral
   First generation 0.03 (0.14) 0.03 (0.13) -0.0046 [-0.014, 0.0043]
   Second generation 0.40 (0.39) 0.38 (0.41) -0.019 [-0.044, 0.0065]
  Long acting-injectable
   First generation 0.07 (0.20) 0.02 (0.11) -0.05 [-0.060, -0.038]
   Second generation N/A (N/A) 0.64 (0.33) N/A
  1. Bolded mean difference indicates statistically significant difference (p < 0.001) between the 2-year post- and 2-year pre-index using paired t-tests. Abbreviations: CI Confidence interval, N/A Not applicable, SD standard deviation