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Table 2 Antipsychotic medication use and mean medication possession ratio of the overall cohort during the pre-index and post-index periods

From: Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study

 

Pre-index period

(n = 1,211; 100%)

Post-index period

(n = 1,211; 100%)

Mean difference

[95% CI]

Received ≥ 1 dispensation, n (%)

 Oral

  First generation

130 (10.7%)

120 (9.9%)

 

  Second generation

966 (79.8%)

841 (69.5%)

 

 Long acting-injectable

  First generation

192 (15.9%)

67 (5.5%)

 

  Second generation

N/A (N/A)

1,211 (100%)

 

Medication possession ratio, mean (SD); mean difference [95%CI]

 Overall

0.45 (0.40)

0.84 (0.26)

0.39 [0.36, 0.41]

  Oral

   First generation

0.03 (0.14)

0.03 (0.13)

-0.0046 [-0.014, 0.0043]

   Second generation

0.40 (0.39)

0.38 (0.41)

-0.019 [-0.044, 0.0065]

  Long acting-injectable

   First generation

0.07 (0.20)

0.02 (0.11)

-0.05 [-0.060, -0.038]

   Second generation

N/A (N/A)

0.64 (0.33)

N/A

  1. Bolded mean difference indicates statistically significant difference (p < 0.001) between the 2-year post- and 2-year pre-index using paired t-tests. Abbreviations: CI Confidence interval, N/A Not applicable, SD standard deviation