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Table 3 Mean healthcare costs during the pre- and post-index periods among the CTO cohorts

From: Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study

 

CTO status

pre = no / post = no

(n = 689; 57%)

pre = yes / post = yes

(n = 275; 23%)

pre = yes / post = no

(n = 133; 11%)

pre = no / post = yes

(n = 114; 9%)

pre-index

post-index

pre-index

post-index

pre-index

post-index

pre-index

post-index

All-Cause, $CDN

Total, mean

(standard deviation)

$61,281 (72,902)

$34,387 (65,056)

$91,342

(74,924)

$51,324 (80,380)

$100,699 (82,557)

$15,987 (22,746)

$79,285 (72,358)

$78,268 (78,204)

difference [95%CI]

-$26,894 [-33472, -20316]

-$40,018 [-51363, -28673]

-$84,712 [-98938, -70486]

-$1017 [-19082, 17048]

Hospitalizations, mean

(standard deviation)

$44,871 (62,059)

$23,016 (52,911)

$66,326 (60,263)

$36,392 (67,225)

$76,597 (72,378)

$7913 (17,777)

$59,026 (59,563)

$55,499 (63,312)

difference [95%CI]

-$21,855 [-27526, -16185]

-$29,934 [-39438, -20430]

-$68,684 [-81158, -56210]

-$3527 [-18210, 11156]

Physician visits, mean

(standard deviation)

$14,013 (12,111)

$9759 (12,641)

$22,347

(15,303)

$13,266 (13,551)

$21,861 (12,627)

$7300

(5654)

$17,297 (13,275)

$20,039 (14,477)

difference [95%CI]

-$4254 [-5286, -3222]

-$9081 [-11093, -7069]

-$14,561 [-16684, -12439]

$2742 [-682, 6166]

ED visits, mean

(standard deviation)

$2396 (3768)

$1612 (4258)

$2669 (2892)

$1666 (2400)

$2241 (1988)

$774 (1412)

$2962 (3593)

$2730 (3335)

difference [95%CI]

-$785 [-1038, -531]

-$1002 [-1310, -695]

-$1467 [-1811, -1123]

-$232 [-933, 469]

Mental health-related, $CDN

Total, mean

(standard deviation)

$55,360 (68,443)

$27,965 (59,719)

$86,532 (73,380)

$44,222 (74,477)

$92,753 (73,726)

$13,974 (22,046)

$75,092 (71,688)

$71,361 (70,648)

difference [95%CI]

-$27,395 [-33667, -21122]

-$42,311 [-53047, -31575]

-$78,779 [-91476, -66082]

-$3731 [-20470, 13008]

Hospitalizations, mean

(standard deviation)

$41,827 (59,543)

$19,300 (49,347)

$64,106 (59,601)

$31,838 (61,986)

$70,814 (63,850)

$7188 (17,376)

$57,283 (59,364)

$51,652 (57,815)

difference [95%CI]

-$22,527 [-27964, -17090]

-$32,268 [-41216, -23319]

-$63,626 [-74636, -52616]

-$5631 [-19328, 8067]

Physician visits, mean

(standard deviation)

$12,128 (10,663)

$78,456 (11,155)

$20,546 (14,677)

$11,340 (12,711)

$20,243 (12,104)

$6316 (5398)

$15,773 (12,989)

$17,972 (13,319)

difference [95%CI]

-$4282 [-5248, -3316]

-$9206 [-11138, -7274]

-$13,927 [-15957, -11897]

$2200 [-996, 5395]

ED visits, mean

(standard deviation)

$1405 (2080)

$819 (2314)

$1881 (1978)

$1044 (1769)

$1696 (1417)

$470 (967)

$2036 (2588)

$1736 (2066)

difference [95%CI]

-$586 [-742, -430]

-$837 [-1055, -619]

-$1226 [-1472, -980]

-$300 [-799, 198]

  1. Bolded mean difference indicates statistically significant difference (p < 0.001) between the 2-year post- and 2-year pre-index periods using paired t-tests. Abbreviations: CDN Canadian, CI Confidence interval, CTO Community treatment order, ED Emergency department