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Table 2 Input parameters of the cost-effectiveness model of rTMS add-on treatment versus standard therapy

From: Repetitive transcranial magnetic stimulation may be a cost-effective alternative to antidepressant therapy after two treatment failures in patients with major depressive disorder

Description

Base case

Min

Max

SD (± 20%)

Distribution

Source

Probabilities for treatment decisions

 getting ECT in no response condition in step 3

0,1

0,08

0,12

0,0102

beta

survey (S3)

 getting ECT for the 1st time in no response condition in step 4

0,25

0,20

0,30

0,0255

beta

survey (S3)

 getting ECT repeatedly in no response condition in step 4

0,05

0,04

0,06

0,0051

beta

survey (S3)

 starting maintenance in step 3

0,65

0,52

0,78

0,0663

beta

survey (S3)

 retreatment with rTMS after relapse if there was no maintenance rTMS therapy

0,79

0,63

0,95

0,0806

beta

survey (S3)

 retreatment with rTMS after relapse when there was a maintenance rTMS therapy

0,78

0,62

0,94

0,0796

beta

survey (S3)

 getting hospitalized during acute episode

0,4

0,32

0,48

0,0408

gamma

survey (S3)

Transition probabilities

 relapse after partial remission from drug therapy in step 3

0,614

0,49

0,74

0,0627

beta

[23]

 relapse after partial remission from drug therapy in step 4

0,64

0,51

0,77

0,0653

beta

[23]

 relapse after remission from drug therapy in step 3

0,25

0,20

0,30

0,0255

beta

[23]

 relapse after remission from drug therapy in step 4

0,426

0,34

0,51

0,0435

beta

[23]

 relapse after maintenance rTMS

0,173

0,14

0,21

0,0177

beta

[29]

 relapse after no maintenance rTMS

0,494

0,40

0,59

0,0504

beta

[29]

 remission drug therapy step 3

0,137

    

[23]

 remission drug therapy step 4

0,13

    

[23]

 remission when receiving ECT

0,581

    

[24]

 remission with rTMS in step 3

0,363

0,181

0,728

0,1394

beta

meta-analysis (S1)

 remission with rTMS in step 4

0,345

0,172

0,690

0,1323

beta

meta-analysis (S1)

 partial response when using drug therapy step 3

0,168

    

[23]

 partial response when using drug therapy step 4

0,163

    

[23]

 partial response after ECT

0,262

    

[24]

Risk ratios

 RR of remission with rTMS

2,65

1,32

5,31

  

meta-analysis (S1)

 RR of partial response after rTMS

1

    

assumption

Utilities

 incremental utility of partial remission

0,13

0,10

0,17

0,0179

gamma

[25]

 incremental utility of remission

0,26

0,22

0,29

0,0179

gamma

[25]

 baseline utility of no response

0,56

    

[25]