Description | Base case | Min | Max | SD (± 20%) | Distribution | Source |
---|---|---|---|---|---|---|
Probabilities for treatment decisions | ||||||
getting ECT in no response condition in step 3 | 0,1 | 0,08 | 0,12 | 0,0102 | beta | survey (S3) |
getting ECT for the 1st time in no response condition in step 4 | 0,25 | 0,20 | 0,30 | 0,0255 | beta | survey (S3) |
getting ECT repeatedly in no response condition in step 4 | 0,05 | 0,04 | 0,06 | 0,0051 | beta | survey (S3) |
starting maintenance in step 3 | 0,65 | 0,52 | 0,78 | 0,0663 | beta | survey (S3) |
retreatment with rTMS after relapse if there was no maintenance rTMS therapy | 0,79 | 0,63 | 0,95 | 0,0806 | beta | survey (S3) |
retreatment with rTMS after relapse when there was a maintenance rTMS therapy | 0,78 | 0,62 | 0,94 | 0,0796 | beta | survey (S3) |
getting hospitalized during acute episode | 0,4 | 0,32 | 0,48 | 0,0408 | gamma | survey (S3) |
Transition probabilities | ||||||
relapse after partial remission from drug therapy in step 3 | 0,614 | 0,49 | 0,74 | 0,0627 | beta | [23] |
relapse after partial remission from drug therapy in step 4 | 0,64 | 0,51 | 0,77 | 0,0653 | beta | [23] |
relapse after remission from drug therapy in step 3 | 0,25 | 0,20 | 0,30 | 0,0255 | beta | [23] |
relapse after remission from drug therapy in step 4 | 0,426 | 0,34 | 0,51 | 0,0435 | beta | [23] |
relapse after maintenance rTMS | 0,173 | 0,14 | 0,21 | 0,0177 | beta | [29] |
relapse after no maintenance rTMS | 0,494 | 0,40 | 0,59 | 0,0504 | beta | [29] |
remission drug therapy step 3 | 0,137 | [23] | ||||
remission drug therapy step 4 | 0,13 | [23] | ||||
remission when receiving ECT | 0,581 | [24] | ||||
remission with rTMS in step 3 | 0,363 | 0,181 | 0,728 | 0,1394 | beta | meta-analysis (S1) |
remission with rTMS in step 4 | 0,345 | 0,172 | 0,690 | 0,1323 | beta | meta-analysis (S1) |
partial response when using drug therapy step 3 | 0,168 | [23] | ||||
partial response when using drug therapy step 4 | 0,163 | [23] | ||||
partial response after ECT | 0,262 | [24] | ||||
Risk ratios | ||||||
RR of remission with rTMS | 2,65 | 1,32 | 5,31 | meta-analysis (S1) | ||
RR of partial response after rTMS | 1 | assumption | ||||
Utilities | ||||||
incremental utility of partial remission | 0,13 | 0,10 | 0,17 | 0,0179 | gamma | [25] |
incremental utility of remission | 0,26 | 0,22 | 0,29 | 0,0179 | gamma | [25] |
baseline utility of no response | 0,56 | [25] |