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Table 4 Depression (PHQ-9) and anxiety (GAD-7) scores by number of IM ketamine treatments received

From: Real-world depression, anxiety and safety outcomes of intramuscular ketamine treatment: a retrospective descriptive cohort study

 

Na

Score at Baseline

Median (IQR)

Score at Last Treatment

Median (IQR)

p-valueb

Depression – PHQ-9

 All treatment lengths

112

16.0 (11.3–21.8)

10.0 (6.0–15.0)

<.001

 Patients with 1 treatment

66

13.5 (8.0–21.0)

N/A

N/A

 Patients with 2–4 treatments

30

15.0 (7.8–21.0)

12.0 (5.8–15.0)

<.001

 Patients with 5–6 treatments

38

17.0 (12.5–22.5)

9.0 (6.0–13.0)

<.001

 Patients with 7–10 treatments

29

15.0 (11.5–22.0)

10.0 (7.0–15.0)

.001

 Patients with 11–48 treatments

15

20.0 (15.0–24.0)

11.0 (6.0–13.0)

<.001

Anxiety – GAD-7

 All treatment lengths

80

14.0 (8.0–17.0)

7.0 (4.3–11.8)

<.001

 Patients with 1 treatment

50

10.5 (6.0–16.0)

N/A

N/A

 Patients with 2–4 treatments

24

10.0 (7.0–14.8)

8.0 (7.8–13.8)

.061

 Patients with 5–6 treatments

26

15.5 (11.0–17.0)

7.0 (4.0–11.3)

<.001

 Patients with 7–10 treatments

20

10.5 (6.0–18.3)

7.5 (5.0–9.8)

.006

 Patients with 11–48 treatments

10

17.5 (15.5–18.3)

8.5 (5.3–11.0)

.003

  1. aOnly patients with an IM ketamine treatment duration greater than 2 weeks and survey scores available at first and last IM ketamine treatment were included; bWilcoxon signed-rank tests were conducted; bold lettering = significant change based on a Bonferroni adjusted α of .01