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Table 2 Brain regions showing significant main effects of diagnosis and BMI in VBM analysis*

From: Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia

Brain region

Cluster size (voxels)

F value

MNI coordinate

X

Y

Z

Main effects of diagnosis

 Hippocampus

R

1307

30.1

16.5

-12

-12

 Insula

L

2511

28.3

-45

4.5

-7.5

 Insula

R

1031

19.1

54

21

1.5

 Rectus

B

1110

22.9

7.5

37.5

-21

 Cingulum-Mid

B

1224

21.1

-7.5

-31.5

42

 Thalamus

B

1934

25.3

1.5

-18

-3

Main effects of BMI

 Amygdala

R

1982

24.8

37.5

-1.5

-5.5

 Hippocampus

L

4339

27.2

-30

4.5

-34.5

 Insula

L

1626

19.7

-24

22.5

-6

 Insula

R

668

19.2

40.5

30

4.5

 Lingual

L

1383

26.0

-24

-63

-1.5

 Temporal_sup

R

1254

23.9

67.5

-13.5

4.5

  1. SZ Schizophrenia, OWB Overweight or obesity, L Left, R Right, B Bilateral, Cingulum-Mid Median cingulate and paracingulate gyri, Temporal_sup Superior temporal gyrus, MNI Montréal neurological institute
  2. *p < 0.001, FWE corrected