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Table 3 Pearson’s partial correlations between brain GMV and clinical symptoms

From: Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia

3a: Brain regions showing significant main effects of diagnosisa

 

Cingulum_Mid

(r, p)

Insula-L

(r, p)

Insula-R (r, p)

HIP-R

(r, p)

Rectus

(r, p)

Thalamus

(r, p)

PANSS total

-0.001, 0.991

-0.036, 0.678

-0.106, 0.218

0.005, 0.957

0.041, 0.634

-0.035, 0.685

PANSS positive

-0.061, 0.481

0.042, 0.627

-0.037, 0.671

-0.022, 0.801

-0.143, 0.094

0.046, 0.591

PANSS negative

-0.141, 0.100

-0.254, 0.003

-0.301, 0.000

-0.071, 0.412

-0.180, 0.035

-0.139, 0.105

PANSS general psychopathology

0.097, 0.260

0.045, 0.600

0.002, 0.978

0.052, 0.548

0.222, 0.009

-0.010, 0.904

MoCA total

0.082, 0.342

0.160, 0.062

0.192, 0.025

0.142, 0.099

0.114, 0.184

0.137, 0.110

Visuospatial/constructional

0.044, 0.611

0.148, 0.084

0.163, 0.057

0.191, 0.026

0.098, 0.253

0.197, 0.021

Naming

-0.012, 0.890

0.039, 0.654

0.015, 0.866

0.087, 0.310

0.031, 0.723

0.090, 0.294

Attention

0.154, 0.072

0.250, 0.003

0.250, 0.003

0.157, 0.067

0.151, 0.078

0.256, 0.003

Language

0.006, 0.948

0.053, 0.540

0.112, 0.193

0.044,0.609

0.009, 0.917

-0.014, 0.874

Abstraction

-0.098, 0.252

-0.019, 0.823

0.015, 0.865

-0.045,0.599

0.210, 0.014

-0.074, 0.391

Delayed memory

-0.008, 0.929

0.116, 0.177

0.114, 0.184

0.102, 0.234

-0.025, 0.770

0.026, 0.759

Orientation

0.117, 0.174

-0.015, 0.864

0.059, 0.496

0.069, 0.420

0.024, 0.777

0.053, 0.539

3b: Brain regions showing significant main effects of BMIb

 

HIP_L

(r, p)

Insula-L

(r, p)

Insula-R (r, p)

LING_L

(r, p)

AMYG_R

(r, p)

STG_R

(r, p)

MoCA total

0.012, 0.900

0.180, 0.052

0.118, 0.201

0.013, 0.889

0.362, 0.000

0.360, 0.000

Visuospatial/constructional

0.050, 0.591

0.058, 0.532

0.038, 0.684

-0.151,0.103

0.134, 0.149

0.184, 0.046

Naming

-0.106, 0.254

-0.028, 0.762

-0.101, 0.276

0.072, 0.436

0.284, 0.002

0.087, 0.347

Attention

0.066, 0.479

0.253, 0.006

0.260, 0.004

0.158, 0.087

0.287, 0.002

0.302, 0.001

Language

-0.143, 0.123

0.090, 0.332

-0.059, 0.529

-0.168, 0.069

0.087, 0.351

0.116, 0.212

Abstraction

-0.043, 0.643

-0.027, 0.768

-0.059, 0.523

-0.068, 0.465

0.066, 0.478

0.099, 0.287

Delayed memory

0.019, 0.836

0.117, 0.206

0.100, 0.284

0.029, 0.758

0.307, 0.001

0.219, 0.017

Orientation

0.059, 0.523

0.081, 0.385

0.049, 0.595

0.105, 0.256

0.208, 0.024

0.294, 0.001

  1. Significant p-values are shown in bold cases
  2. SZ Schizophrenia, OWB Overweight or obesity, PANSS Positive and Negative Syndrome Scale, MoCA Montreal Cogntive Assessment, L Left, R Right, HIP Hippocampus, AMYG Amygdala, LING Lingual gyrus, STG Superior temporal gyrus, BMI Body mass index, ICV Total intracranial volume
  3. aCorrelations between brain GMV and clinical symptoms (PANSS and MoCA) in the SZ group, controlling for age, sex, education, illness duration, BMI and ICV
  4. bCorrelations between brain GMV and clinical symptoms (MoCA) in OWB group, controlling for age, sex, education, BMI and ICV
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BMC Psychiatry

ISSN: 1471-244X

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