Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder

Table 2 Two-sample t-test results of the whole-brain intrinsic functional connectivity of bilateral insula between the OCD and HC groups

Seed Region	Area	BA	L/R	Voxels	MNI			T peak-values	P _uncorrected	P _{FWE−corrected}
Seed Region	Area	BA	L/R	Voxels	X	Y	Z	T peak-values	P _uncorrected	P _{FWE−corrected}
Left insula
OCD > HC	Precuneus/Inferior Parietal Lobule	31/7	L&R	982	-15	-54	42	5.83	0.000	0.000*
OCD > HC	Supplementary motor area	6	R	242	15	-6	57	3.84	0.001	0.019*
Right insula
OCD > HC	Precuneus/Inferior Parietal Lobule	31/7	L&R	970	-15	-54	42	5.35	0.000	0.000*
	Supplementary motor area	6	L&R	439	-15	-15	54	5.45	0.000	0.000*
OCD < HC	Lingual Gyrus	30/19	L&R	346	36	-42	3	4.04	0.000	0.002*

Abbreviations: OCD: obsessive-compulsive disorder; HC: healthy control; BA: Brodmann areas; MNI: Montreal Neurological Institute; R: right; L: left; FWE: familywise error correction
* P < 0.025 with FWE correction.

ISSN: 1471-244X