Table 1 Causal estimates for daytime napping frequency on schizophrenia by Mendelian randomization. Abbreviations: SNP, single nucleotide polymorphism; IVW, inverse variance weighted; MR-RAPS, Mendelian randomization robust adjusted profile score; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier
Exposure | Outcome | SNPs (n) | Cochran’s Q P-value | MR-Egger pleiotropy test P-value | Methods | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
Daytime Napping Frequency | Schizophrenia | 64 | 1.04E-19 | 0.27 | IVW | 3.48(1.54,7.85) | 2.65E-03 |
Weighted median | 3.30(1.52,7.15) | 2.56E-03 | |||||
MR-RAPS | 4.50(2.92,6.93) | 8.50E-12 | |||||
MR-PRESSO | 3.68(1.65,8.20) | 2.19E-03 | |||||
Radial MR | 3.67(1.65,8.18) | 1.48E-03 | |||||
Daytime Napping Frequency (Without outliers) | Schizophrenia | 47 | 0.154 | 0.68 | IVW | 3.38(2.02,5.65) | 3.58E-06 |
Weighted median | 3.49(1.67,7.27) | 8.57E-04 | |||||
MR-RAPS | 3.55(2.18,5.78) | 3.67E-07 | |||||
MR-PRESSO | 3.38(2.02,5.65) | 2.97E-05 | |||||
Radial MR | 3.37(2.01,5.63) | 3.81E-06 |