Table 2 Causal estimates for schizophrenia on daytime napping frequency by Mendelian randomization. Abbreviations: SNP, single nucleotide polymorphism; IVW, inverse variance weighted; MR-RAPS, Mendelian randomization robust adjusted profile score; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier
Exposure | Outcome | SNPs (n) | Cochran’s Q P-value | MR-Egger pleiotropy test P-value | Methods | beta (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
Schizophrenia | Daytime Napping Frequency | 77 | 4.05E-40 | 0.21 | IVW | 0.0095(0.0012,0.0178) | 2.50E-02 |
Weighted median | 0.0106(0.0035,0.0176) | 3.37E-03 | |||||
MR-RAPS | 0.0102(0.0065,0.0138) | 5.88E-08 | |||||
MR-PRESSO | 0.0090(0.0008,0.0172) | 3.18E-02 | |||||
Radial MR | 0.0090(0.0008,0.0172) | 3.18E-02 | |||||
Schizophrenia (Without outliers) | Daytime Napping Frequency | 51 | 0.173 | 0.67 | IVW | 0.0112(0.0060,0.0163) | 2.04E-05 |
Weighted median | 0.0114(0.0043,0.0185) | 1.67E-03 | |||||
MR-RAPS | 0.0115(0.0066,0.0164) | 3.51E-06 | |||||
MR-PRESSO | 0.0112(0.0060,0.0163) | 9.00E-05 | |||||
Radial MR | 0.0112(0.0060,0.0163) | 2.06E-05 |