Table 4 Associations between death rate for each type of diagnosis and number of additional types of diagnoses

Only F10 (alcohol) or with other types of diagnoses

Only F10: 0.1472 (0.1427-0.1516)

F10+1: 0.1626 (0.1469-0.1783)

F10+2: 0.1853 (0.1608-0.2098)

F10+3 or more: 0.1939 (0.1560-0.2317)

p < 0.0001ⁱ

+1/only F10: 1.105 (0.999-1.222)

p = 0.0548

+2/+1: 1.140 (0.968-1.342)

p = 0.119

+3 or more/+2: 1.046 (0.827-1.323)

p = 0.707

Only F11 (opioids) or with other types of diagnoses

Only F11: 0.1194 (0.0985-0.1404)

+1 type: 0.2092 (0.1828-0.2355)

+2 types: 0.2349 (0.2033-0.2665)

+3 or more: 0.2405 (0.1968-0.2843)

p < 0.0001ⁱ

+1/only F11: 1.751 (1.411-2.173)

p < 0.0001

+2/+1: 0.123 (0.934-1.350)

p = 0.217

+3 or more/+2: 1.024 (0.817-1.283)

p = 0.836

Only F12 (cannabinoids) or with other types of diagnoses

Only F12: 0.0433 (0.0305-0.0561)

+1 type: 0.0713 (0.0488-0.0938)

+2 types: 0.1307 (0.0912-0.1703)

+3 or more: 0.1709 (0.1181-0.2236)

p < 0.0001ⁱ

+1/only F12: 1.646 (1.069-2.536)

p = 0.0227

+2/+1: 1.834 (1.187-2.834)

p = 0.0058

+3 or more/+2: 1.307 (0.851-2.007)

p = 0.2217

Only F13 (sedative hypnotics) or with other types of diagnoses

Only F13: 0.1454 (0.1145-0.1764)

+1 type: 0.2450 (0.2090-0.2810)

+2 types: 0.2413 (0.2071-0.2755)

+3 or more: 0.2359 (0.1926-0.2792)

p < 0.0001ⁱ

+1/only F13: 1.685 (1.302-2.180)

p < 0.0001

+2/+1: 0.985 (0.804-1.207)

p = 0.884

+3 or more/+2: 0.978 (0.776-1.232)

p = 0.8477

Only F14 (cocaine) or with other types of diagnoses

Only F14: 0.0303 (0.0080-0.0526)

+1 type: 0.0629 (0.0227-0.1032)

+2 types: 0.0755 (0.0244-0.1266)

+3 or more: 0.1714 (0.0809-0.2619)

p = 0.0005ⁱ

+1/only F14: 2.077 (0.791-5.454)

p = 0.1301

+2/+1: 1.199 (0.479-3.005)

p = 0.6988

+3 or more/+2: 2.271 (0.979-5.273)

p = 0.0503

Only F15 (other stimulants, incl caffeine) or with other types of diagnoses

Only F15: 0.0829 (0.0642-0.1017)

+1 type: 0.1055 (0.0839-0.1272)

+2 types: 0.1433 (0.1157-0.1710)

+3 or more: 0.1619 (0.1233-0.2006)

p < 0.0001ⁱ

+1/only F15: 1.273 (0.938-1.726)

p = 0.1204

+2/+1: 1.358 (1.025-1.798)

p = 0.0322

+3 or more/+2: 1.130 (0.832-1.534)

p = 0.4349

Only F19 (multiple drug use of other psychoactive substances) or with other types of diagnoses

Only F19: 0.0992 (0.0897-0.1088)

+1 type: 0.1513 (0.1387-0.1638)

+2 types: 0.1928 (0.1730-0.2126)

+3 or more: 0.2051 (0.1713-0.2389)

p < 0.0001ⁱ

+1/only F19: 1.524 (1.342-1.731)

p < 0.0001

+2/+1: 1.274 (1.117-1.454)

p = 0.0003

+3 or more/+2: 1.064 (0.876-1.291)

p = 0.5334