CYP2C19-rs4986893 confers risk to major depressive disorder and bipolar disorder in the Han Chinese population whereas ABCB1-rs1045642 acts as a protective factor

Zhang, Ting; Rao, Qingmin; Lin, Kangguang; He, Yongyin; Cai, Jintai; Yang, Mengxin; Xu, Ying; Hou, Le; Lin, Yulong; Liu, Haiying

doi:10.1186/s12888-022-04514-w

Table 3 Genotype distribution of SNPs in all groups

From: CYP2C19-rs4986893 confers risk to major depressive disorder and bipolar disorder in the Han Chinese population whereas ABCB1-rs1045642 acts as a protective factor

Gene	SNP ID		Genotype distribution			MAF	χ2	P	OR	95%CI	Statistical power
LEPR	rs1137101		AA	AG	GG
		Control	11	105	348	0.1369
		MDD	5	86	348	0.1093	3.156	0.076	0.774	0.584–1.027	28%
		BPD	10	120	470	0.1167	1.943	0.163	0.833	0.644–1.077	18%
SCN2A	rs17183814		GG	AG	AA
		Control	359	98	7	0.1207
		MDD	297	131	11	0.1743	10.34	0.001	1.538	1.181–2.001	62%
		BPD	416	168	16	0.1667	8.841	0.003	1.457	1.136–1.869	56%
SCN1A	rs2298771		AA	AG	GG
		Control	387	73	4	0.0873
		MDD	357	75	7	0.1014	1.049	0.306	1.18	0.860–1.618	10%
		BPD	498	97	5	0.0892	0.023	0.879	1.024	0.757–1.385	12%
SCN1A	rs3812718		GG	AG	AA
		Control	72	228	164	0.4009
		MDD	74	206	159	0.4032	0.01	0.92	1.01	0.837–1.219	1%
		BPD	100	275	225	0.3958	0.055	0.814	0.979	0.822–1.166	5%
UGT1A9	rs2741049		TT	CT	CC
		Control	152	221	91	0.4343
		MDD	149	198	92	0.4351	0.001	0.972	1.003	0.833–1.209	5%
		BPD	167	309	124	0.4642	1.889	0.169	1.128	0.950–1.341	16%
GSK3B	rs334558		TT	CT	CC
		Control	56	212	196	0.3491
		MDD	54	200	185	0.3508	0.005	0.941	1.007	0.830–1.222	5%
		BPD	83	287	230	0.3775	1.816	0.178	1.13	0.946–1.351	15%
HLA-B	rs2442736		GG	GC	CC
		Control	422	42	0	0.0453
		MDD	385	53	1	0.0626	2.682	0.102	1.41	0.933–2.130	23%
		BPD	544	54	2	0.0483	0.111	0.74	1.071	0.713–1.609	6%
ABCB1	rs1045642		CC	CT	TT
		Control	137	249	78	0.4364
		MDD	177	208	54	0.3599	11.01	0.001	0.726	0.601–0.877	67%
		BPD	244	268	88	0.3700	9.628	0.002	0.758	0.637–0.903	61%
NAT2	rs1041983		CC	CT	TT
		Control	144	225	95	0.4472
		MDD	130	230	79	0.4419	0.051	0.821	0.979	0.813–1.179	5%
		BPD	182	300	118	0.4467	0.001	0.981	0.998	0.840–1.186	5%
NAT2	rs1801280		TT	CT	CC
		Control	416	40	8	0.0603
		MDD	400	38	1	0.0456	1.96	0.162	0.743	0.490–1.127	17%
		BPD	554	44	2	0.0400	4.66	0.031	0.649	0.437–0.964	33%
NAT2	rs1799929		CC	CT	TT
		Control	430	32	2	0.0388
		MDD	390	45	4	0.0604	4.481	0.034	1.592	1.032–2.456	33%
		BPD	553	45	2	0.0408	0.057	0.812	1.055	0.680–1.636	36%
NAT2	rs1799930		GG	AG	AA
		Control	264	176	24	0.2414
		MDD	231	182	26	0.2665	1.506	0.22	1.142	0.924–1.412	14%
		BPD	312	250	38	0.2717	2.505	0.114	1.172	0.963–1.427	20%
NAT2	rs1208		AA	AG	GG
		Control	416	44	4	0.0560
		MDD	400	37	2	0.0467	0.805	0.37	0.825	0.542–1.256	11%
		BPD	553	45	2	0.0408	2.675	0.102	0.717	0.481–1.070	27%
CYP2C19	rs12248560		CC	CT	TT
		Control	460	4	0	0.0043
		MDD	434	5	0	0.0057	0.174	0.676	1.323	0.354–4.943	----
		BPD	594	6	0	0.0050	0.053	0.818	1.161	0.327–4.125	----
CYP2C19	rs4986893		GG	AG	AA
		Control	440	24	0	0.0259
		MDD	393	44	2	0.0547	9.781	0.002	2.178	1.323–3.588	66%
		BPD	536	64	0	0.0533	9.962	0.002	2.122	1.317–3.420	67%
CYP2C19	rs4244285		GG	AG	AA
		Control	256	168	40	0.2672
		MDD	219	179	41	0.2973	2.009	0.156	1.16	0.945–1.424	17%
		BPD	275	263	62	0.3225	7.633	0.006	1.305	1.080–1.577	50%
CYP2C9	rs1057910		AA	AC	CC
		Control	433	31	0	0.0334
		MDD	406	33	0	0.0376	0.231	0.631	1.13	0.686–1.862	6%
		BPD	568	32	0	0.0267	0.827	0.363	0.793	0.480–1.309	10%
ANKK1	rs1800497		GG	AG	AA
		Control	168	208	88	0.4138
		MDD	143	224	72	0.4191	0.053	0.818	1.022	0.848–1.233	5%
		BPD	202	290	108	0.4217	0.133	0.715	1.033	0.868–1.229	6%
SH2B1	rs3888190		CC	AC	AA
		Control	396	63	5	0.0787
		MDD	365	68	6	0.0911	0.902	0.342	1.174	0.843–1.636	10%
		BPD	498	93	9	0.0925	1.268	0.26	1.194	0.877–1.625	12%
INSR	rs2396185		AA	AC	CC
		Control	336	124	4	0.1422
		MDD	328	101	10	0.1378	0.073	0.786	0.964	0.739–1.258	5%
		BPD	408	171	21	0.1775	4.789	0.029	1.301	1.027–1.648	33%

χ², P, OR, and 95%CI in this table indicate chi-square value, P value, odds ratio, and 95% confidence interval of minor alleles, respectively
MAF Minor allele frequency

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ISSN: 1471-244X

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