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Table 5 CYP2C19 metabolizer status distribution in controls and cases with MDD and BPD

From: CYP2C19-rs4986893 confers risk to major depressive disorder and bipolar disorder in the Han Chinese population whereas ABCB1-rs1045642 acts as a protective factor

 

Control(n = 464)

MDD(n = 439)

BPD(n = 600)

   

NM

248 (53.45%)

187 (42.60%)

233 (38.83%)

   

IM

160 (34.48%)

195 (44.42%)

283 (47.17%)

   

PM

56 (12.07%)

57 (12.98%)

84 (14.00%)

   

IM&PM

216 (46.55%)

252 (57.40%)

367 (61.17%)

   
 

MDD

BPD

 

χ2

P

OR (CI 95%)

χ2

P

OR (95% CI)

NM vs. IM vs. PM

11.330

0.003

––

23.215

 < 0.001

––

IM&PM vs. NM

10.639

0.001

1.547(1.190,2.012)

22.563

 < 0.001

1.808(1.415,2.311)

  1. NM Normal metabolizer, IM Intermediate metabolizer, PM Poor metabolizer, IM&PM Intermediate metabolizers plus poor metabolizers
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BMC Psychiatry

ISSN: 1471-244X

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