Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry

Table 3 Association of epigenetic aging acceleration estimated by three clocks with the cognitive function improvement in drug-naive first-episode SCZ after 8 weeks resperidone treatment

Cognition Valuable	Horvath’s AgeAccel		Hannum’s AgeAccel		Levine’s PhenoAgeAccel
Cognition Valuable	β	P value	β	P value	β	P value
DST-F	0.02	0.92	−0.12	0.50	−0.13	0.48
DST-B	−0.05	0.77	0.34	0.04	0.04	0.82
VFT	0.09	0.63	0.20	0.27	0.35	0.06
Stroop-W	−0.34	0.04	−0.34	0.04	−0.37	0.03
Stroop-C	−0.16	0.38	−0.46	0.01	−0.32	0.07
Stroop-I	0.08	0.67	−0.23	0.19	−0.39	0.03
TMT-A	−0.03	0.87	0.13	0.48	−0.09	0.64
TMT-B	−0.08	0.69	0.03	0.86	0.03	0.89
WCST-C	0.41	0.01	0.15	0.34	0.08	0.64
WCST-PE	0.12	0.49	−0.01	0.98	0.07	0.71

DST-F Digit Span Tests Forward, DST-B Digit Span Tests Backward, VFT Verbal Fluency Test, TMT-A Trail Making Test-Part A, TMT-B Trail Making Test-Part B, Stroop-W Stroop Tests Words, Stroop-C Stroop Tests Colors, Stroop-I Stroop Tests Interference, WCST-C Wisconsin Card Sorting Test categories, WCST-P Wisconsin Card Sorting Test perseverative errors. Multiple linear regression analyses were conducted to assess the relationship between baseline epigenetic age acceleration and improvement of cognitive function in 36 SCZ patients after 8-week treatment adjusting for age, sex, tobacco use, and illness duration. Bold values indicate significant difference (P < 0.05) before Bonferroni correction

ISSN: 1471-244X