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Table 4 No correlations of epigenetic aging acceleration estimated by three clocks with the subcortical volume in drug-naive first-episode SCZ and healthy controls

From: Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

Subcortical volumes

Horvath’s AgeAccel

Hannum’s AgeAccel

Levine’s PhenoAgeAccel

β

P value

β

P value

β

P value

Thalamus_L

0.10

0.23

0.08

0.37

0.19

0.16

Caudate_L

0.12

0.27

0.19

0.06

−0.07

0.49

Putaman_L

0.00

0.98

0.06

0.63

0.00

1.00

Pallidum_L

0.14

0.22

0.05

0.67

0.00

0.99

Hippocampus_L

−0.05

0.65

0.02

0.84

−0.08

0.43

Amygdala_L

0.05

0.60

−0.08

0.42

−0.12

0.24

Accumbens_L

0.11

0.37

0.04

0.74

−0.07

0.57

Thalamus_R

0.05

0.52

−0.04

0.66

−0.07

0.43

Caudate_R

0.14

0.15

0.19

0.06

−0.04

0.70

Putaman_R

0.04

0.67

0.08

0.43

0.01

0.89

Pallidum_R

0.12

0.31

0.01

0.91

0.05

0.64

Hippocampus_R

−0.02

0.88

−0.02

0.88

−0.06

0.58

Amygdala_R

0.04

0.73

−0.09

0.39

−0.04

0.68

Accumbens_R

−0.04

0.74

0.05

0.69

−0.21

0.06

  1. L Left, R Right. Multiple linear regression analyses were conducted to assess the relationship between epigenetic age acceleration and 14 subcortical volumes in 38 SCZ patients and 38 controls at baseline adjusting for age, sex, tobacco use, and intracranial volume