Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry

Table 5 Association of epigenetic aging acceleration estimated by three clocks with the subcortical volume changes in drug-naive first-episode SCZ after 8 weeks resperidone treatment

Subcortical volumes	Horvath’s AgeAccel		Hannum’s AgeAccel		Levine’s PhenoAgeAccel
Subcortical volumes	β	P value	β	P value	β	P value
Thalamus_L	−0.30	0.06	−0.14	0.38	−0.09	0.58
Caudate_L	−0.12	0.48	−0.38	0.01	−0.15	0.36
Putaman_L	0.26	0.11	0.00	0.99	−0.07	0.65
Pallidum_L	−0.01	0.93	0.05	0.74	0.11	0.53
Hippocampus_L	0.13	0.51	−0.12	0.49	−0.30	0.10
Amygdala_L	0.15	0.42	0.01	0.97	−0.18	0.32
Accumbens_L	−0.23	0.22	−0.04	0.82	−0.04	0.83
Thalamus_R	0.06	0.74	0.15	0.38	0.09	0.60
Caudate_R	−0.03	0.86	− 0.23	0.19	0.02	0.90
Putaman_R	−0.12	0.51	−0.15	0.40	−0.16	0.37
Pallidum_R	−0.25	0.18	0.10	0.57	0.09	0.63
Hippocampus_R	−0.21	0.58	−0.08	0.66	−0.06	0.73
Amygdala_R	−0.15	0.43	−0.05	0.80	0.11	0.55
Accumbens_R	−0.43	0.01	−0.15	0.41	−0.02	0.94

L Left, R Right. Multiple linear regression analyses were conducted to assess the relationship between baseline epigenetic age acceleration and changes of subcortical volumes in 38 SCZ patients after 8-week treatment adjusting for age, sex, illness duration, tobacco use, and intracranial volume. Bold values indicate significant difference (P < 0.05) before Bonferroni correction

ISSN: 1471-244X