Table 4 Sensitivity analysis for the association between egg consumption and risk of depressive symptoms in a subset of participants completing at least two waves of the follow-up survey
Egg consumption | Total | Cases | Model 1 | Model 2 | Model 3 | Model 4 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
RR (95% CI) | P value | RR (95% CI) | P value | RR (95% CI) | P value | RR (95% CI) | P value | |||
Sensitivity analysis 1: in participants attending the follow-up survey at least twice | ||||||||||
None or not weekly | 2520 | 600 | 1.00 (Ref) | – | 1.00 (Ref) | – | 1.00 (Ref) | – | 1.00 (Ref) | – |
< 3 eggs/week | 2224 | 360 | 0.60 (0.53–0.68) | < 0.01 | 0.63 (0.55–0.71) | < 0.01 | 0.64 (0.56–0.72) | < 0.01 | 0.69 (0.61–0.78) | < 0.01 |
≥ 3 eggs/week | 2507 | 346 | 0.51 (0.44–0.58) | < 0.01 | 0.54 (0.47–0.61) | < 0.01 | 0.56 (0.49–0.63) | < 0.01 | 0.63 (0.55–0.72) | < 0.01 |
P for trend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||||||
RR for 1 egg/week | 0.93 (0.90–0.96) | < 0.01 | 0.94 (0.91–0.97) | < 0.01 | 0.95 (0.92–0.98) | < 0.01 | 0.96 (0.94–0.99) | 0.01 | ||
Sensitivity analysis 2: included the participants with depressive symptoms at baseline in GEE models | ||||||||||
None or not weekly | 3211 | 918 | 1.00 (Ref) | – | 1.00 (Ref) | – | 1.00 (Ref) | – | 1.00 (Ref) | – |
< 3 eggs/week | 2993 | 712 | 0.79 (0.71–0.86) | < 0.01 | 0.82 (0.75–0.90) | < 0.01 | 0.83 (0.75–0.91) | < 0.01 | 0.85 (0.77–0.93) | < 0.01 |
≥ 3 eggs/week | 3219 | 568 | 0.57 (0.52–0.64) | < 0.01 | 0.61 (0.55–0.68) | < 0.01 | 0.64 (0.57–0.71) | < 0.01 | 0.71 (0.64–0.79) | < 0.01 |
P for trend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||||||
RR for 1 egg/week | 0.94 (0.92–0.96) | < 0.01 | 0.95 (0.93–0.97) | < 0.01 | 0.96 (0.94–0.98) | < 0.01 | 0.97 (0.95–0.99) | < 0.01 | ||
Sensitivity analysis 3: using the PHQ-9 score ≥ 9 to define depressive symptoms | ||||||||||
None or not weekly | 3021 | 286 | 1.00 (Ref) | – | 1.00 (Ref) | – | 1.00 (Ref) | – | 1.00 (Ref) | – |
< 3 eggs/week | 2765 | 174 | 0.65 (0.54–0.79) | < 0.01 | 0.69 (0.57–0.84) | < 0.01 | 0.71 (0.59–0.86) | < 0.01 | 0.76 (0.63–0.92) | < 0.01 |
≥ 3 eggs/week | 3016 | 160 | 0.53 (0.43–0.64) | < 0.01 | 0.58 (0.47–0.70) | < 0.01 | 0.61 (0.50–0.74) | < 0.01 | 0.71 (0.58–0.86) | < 0.01 |
P for trend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||||||
RR for 1 egg/week | 0.89 (0.85–0.94) | < 0.01 | 0.91 (0.87–0.95) | < 0.01 | 0.92 (0.88–0.96) | < 0.01 | 0.95 (0.90–0.99) | 0.02 | ||