Table 1 Result of molecular function and cellular component enrichment analysis for SCZ-OCD common genes

GO: Molecular Functions

Neurotransmitter receptor activity

8.42E-27

GABRG2,DRD1,DRD2,DRD3,HTR1A,DRD4,HTR1B,HTR2A,HTR3A,HTR7,HTR3E,

GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,GRM5,GABBR1,GABRA1

Transmitter-gated ion channel activity

6.02E-15

GABRG2,HTR3A,HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,GABRA1

Signaling receptor activity

6.02E-15

GABRG2,DRD1,DRD2,DRD3,HTR1A,DRD4,HTR1B,NRXN3,HTR2A,OXTR,

HTR3A,NRXN1,HTR7,NTRK1,NTRK2,ESR1,HLA-DRB1,NTRK3,ESR2,NPSR1,

HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,NR3C1,GRM5,

FAS,NPY,GABBR1,GABRA1,OPRM1

Molecular transducer activity

6.02E-15

GABRG2,DRD1,DRD2,DRD3,HTR1A,DRD4,HTR1B,NRXN3,HTR2A,OXTR,

HTR3A,NRXN1,HTR7,NTRK1,NTRK2,ESR1,HLA-DRB1,NTRK3,ESR2,NPSR1,HTR3E,

GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,NR3C1,

GRM5,FAS,NPY,GABBR1,GABRA1,OPRM1

Postsynaptic neurotransmitter receptor activity

6.02E-15

GABRG2,DRD1,DRD2,DRD3,DRD4,GRIA2,GRIA3,GRIK2,GRIK3,GRIN2B,

GRM5,GABBR1,GABRA1

Transmembrane signaling receptor activity

8.26E-14

GABRG2,DRD1,DRD2,DRD3,HTR1A,DRD4,HTR1B,HTR2A,OXTR,HTR3A,

NRXN1,HTR7,NTRK1,NTRK2,HLA-DRB1,NTRK3,NPSR1,HTR3E,GRIA2,

GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,GRM5,

FAS,NPY,GABBR1,GABRA1,OPRM1

Glutamate binding

2.09E-12

GAD1,GAD2,GRIA2,GRIA3,GRIK2,GRIK3,GRIN2B,GRM5,SLC1A1

Ligand-gated ion channel activity

6.77E-12

GABRG2,HTR3A,KCNH2,HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,

GRIN2B,HTR3B,GABRA1

Dopamine binding

8.19E-12

SLC6A3,TH,DRD1,DRD2,DRD3,DRD4

Transmembrane transporter activity

8.19E-12

SLC6A3,SLC6A4,GABRG2,DRD4,HTR1B,NRXN3,HTR3A,NRXN1,SLC18A1,SLC18A2,KCNH2,UCP2,

HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,SLC1A1,SLC1A2,NPY,GABRA1,

ABCB1,OPRM1,KCNH5

Passive transmembrane transporter activity

8.19E-12

GABRG2,DRD4,HTR1B,NRXN3,HTR3A,NRXN1,KCNH2,HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,

GRIK2,GRIK3,GRIN2B,HTR3B,SLC1A1,NPY,GABRA1,OPRM1,KCNH5

Serotonin-gated cation-selective channel activity

5.90E-11

HTR3A,HTR3E,HTR3C,HTR3D,HTR3B

Inorganic molecular entity transmembrane transporter activity

6.33E-11

SLC6A3,SLC6A4,GABRG2,DRD4,HTR1B,HTR3A,SLC18A1,SLC18A2,KCNH2,HTR3E,GRIA2,GRIA3,HTR3C,

HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,SLC1A1,SLC1A2,GABRA1,ABCB1,OPRM1,KCNH5

Ligand-gated cation channel activity

1.04E-10

HTR3A,KCNH2,HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B

Monooxygenase activity

1.09E-10

TH,CYP2C19,CYP2D6,CYP2E1,CYP3A4,CYP3A5,ESR1,TPH2,AKT1,DBH,TPH1

serotonin binding

1.18E-10

SLC6A4,HTR1A,DRD4,HTR1B,HTR2A,HTR3A,MAOA,HTR7

Amine binding

1.71E-10

SLC6A4,HTR1A,DRD4,HTR1B,HTR2A,HTR3A,MAOA,HTR7

Cation transmembrane transporter activity

1.74E-10

SLC6A3,SLC6A4,DRD4,HTR1B,HTR3A,SLC18A1,SLC18A2,KCNH2,HTR3E,GRIA2,

GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,SLC1A1,SLC1A2,OPRM1,KCNH5

Amino acid binding

2.37E-10

GAD1,GAD2,TH,GRIA2,GRIA3,GRIK2,GRIK3,GRIN2B,GRM5,SLC1A1

Ion channel activity

3.41E-10

GABRG2,DRD4,HTR1B,HTR3A,KCNH2,HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,

GRIN2B,HTR3B,SLC1A1,GABRA1,OPRM1,KCNH5

Catecholamine binding

4.35E-10

SLC6A3,TH,DRD1,DRD2,DRD3,DRD4

Ion transmembrane Transporter activity

4.95E-10

SLC6A3,SLC6A4,GABRG2,DRD4,HTR1B,HTR3A,SLC18A1,SLC18A2,KCNH2,HTR3E,GRIA2,

GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,SLC1A1,SLC1A2,GABRA1,ABCB1,OPRM1,KCNH5

Neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

2.58E-09

GABRG2,GRIA2,GRIA3,GRIK2,GRIK3,GRIN2B,GABBR1,GABRA1

Cation channel activity

9.12E-09

DRD4,HTR1B,HTR3A,KCNH2,HTR3E,GRIA2,GRIA3,HTR3C,HTR3D,GRIK2,GRIK3,GRIN2B,HTR3B,OPRM1,KCNH5

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

9.29E-09

TH,CYP2C19,CYP2D6,CYP2E1,CYP3A4,CYP3A5,ESR1,TPH2,AKT1,DBH,TPH1

Dopamine neurotransmitter receptor activity

3.34E-08

DRD1,DRD2,DRD3,DRD4

Glutamate receptor activity

3.39E-08

GRIA2,GRIA3,GRIK2,GRIK3,GRIN2B,GRM5

GO: Cellular Components

Neuron projection

1.89E-38

SLC6A3,SLC6A4,GABRG2,GAD1,GAD2,TH,DRD1,DRD2,HTR1A,DRD4,HTR1B,HTR2A,HTR3A,COMT,NRCAM,NRXN1, HTR7,MAP2,SLC18A1,MTOR,SLC18A2,NTRK1,NTRK2,ESR1,NTRK3,ESR2,HTR3E,TPH2,CNTNAP2,ARC,SYP,

GRIA2, GRIA3,DLG4,HTR3C,HTR3D,GRIK2,GRIK3,DBH,GRIN2B,HTR3B,CTNNB1,NR3C1,GRM5,FAS,CREB1,

SLC1A1, SLC1A2, AR,HOMER1,CRH,BDNF,NPY,GABBR1,SOD1,GABRA1,OPRM1,TPH1

Synapse

6.03E-35

SLC6A3,SLC6A4,GABRG2,GAD1,GAD2,TH,DRD1,DRD2,DRD3,HTR1A,DRD4,HTR1B,NRXN3,HTR2A,HTR3A,

COMT,NRCAM,NRXN1,HTR7,MAP2,SLC18A1,MTOR,SLC18A2,NTRK2,ESR1,NTRK3,HTR3E,CNTNAP2,

ARC,SYP,GRIA2,GRIA3,DLG4,HTR3C,HTR3D,AKT1,GRIK2,GRIK3,DBH,GRIN2B,HTR3B,CTNNB1,NR3C1,GRM5,

SLC1A1,SLC1A2,HOMER1,CRH,BDNF,NPY,GABBR1,NOS1AP,GABRA1,OPRM1

Somatodendritic compartment

1.10E-30

SLC6A3,GABRG2,TH,DRD1,DRD2,HTR1A,DRD4,HTR1B,HTR2A, HTR3A,COMT,NRXN1,HTR7,MAP2,

MTOR,SLC18A2,NTRK1, NTRK2,ESR1,ESR2,CNTNAP2,ARC,GRIA2,GRIA3,DLG4,GRIK2,

GRIK3,DBH,GRIN2B,HTR3B,CTNNB1,NR3C1,GRM5,FAS,SLC1A1,SLC1A2,AR,HOMER1,CRH,BDNF,NPY,

GABBR1,SOD1,GABRA1,OPRM1

Neuronal cell body

1.85E-25

SLC6A3,TH,DRD1,DRD2,HTR1A,DRD4,HTR2A,HTR3A,NRXN1,HTR7, MAP2,MTOR,SLC18A2,NTRK1,NTRK2,ESR1,

ESR2, CNTNAP2,ARC,GRIA2,GRIA3,GRIK2,GRIK3, DBH,GRIN2B,HTR3B,FAS,SLC1A1, HOMER1,CRH,

BDNF,NPY,GABBR1,SOD1,OPRM1

Dendritic tree

2.07E-25

GABRG2,TH,DRD1,DRD2,HTR1A,DRD4,HTR1B,HTR2A,COMT,HTR7, MAP2,MTOR,NTRK1,NTRK2,CNTNAP2,

ARC,GRIA2,GRIA3,DLG4, GRIK2,GRIK3,DBH,GRIN2B,CTNNB1,NR3C1,GRM5,FAS,SLC1A1,

SLC1A2,AR,HOMER1,BDNF,GABBR1,SOD1,GABRA1,OPRM1

Intrinsic component of synaptic membrane

1.23E-24

SLC6A3,SLC6A4,GABRG2,DRD1,DRD2,DRD3,HTR1A,DRD4, HTR1B,HTR2A,HTR3A,NRCAM,NRXN1,

HTR7,NTRK3,GRIA2,GRIA3,DLG4,GRIN2B,GRM5,SLC1A2,GABBR1,GABRA1,OPRM1

glutamatergic synapse

2.06E-18

GABRG2,DRD1,DRD2,DRD3,DRD4,HTR2A,HTR3A,NRCAM,NRXN1, MTOR,NTRK2,NTRK3,ARC,GRIA2,GRIA3,

DLG4,GRIK2,GRIK3, GRIN2B,NR3C1,GRM5,SLC1A2,HOMER1,GABBR1,NOS1AP

Neuron spine

5.57E-18

DRD1,DRD2,DRD4,COMT,NTRK2,CNTNAP2,ARC,SYP,GRIA2, GRIA3,DLG4,GRIK2,GRIN2B,

NR3C1,GRM5,SLC1A1,SLC1A2, HOMER1,GABBR1,OPRM1

Distal axon

2.31E-17

GAD1,TH,DRD1,DRD2,DRD4,HTR1B,NRXN1,HTR7,MAP2,SLC18A1, SLC18A2,NTRK2,ESR1,SYP,

GRIA2,GRIA3,GRIK2,GRIK3, DBH,GRIN2B,SLC1A1,BDNF,NPY

Terminal bouton

4.14E-16

TH,DRD4,SLC18A1,SLC18A2,NTRK2,ESR1,SYP,GRIA2, GRIA3,GRIK2,GRIK3,DBH,

GRIN2B,BDNF,NPY

Dendritic spine

1.68E-15

DRD1,DRD2,DRD4,COMT,NTRK2,ARC,GRIA2,GRIA3,DLG4,GRIK2,GRIN2B,NR3C1,GRM5,SLC1A1,SLC1A2,

HOMER1,GABBR1,OPRM1

Dendritic shaft

1.46E-13

DRD1,HTR2A,MAP2,GRIA2,GRIA3,CTNNB1,GRM5,SLC1A1,SLC1A2,HOMER1,GABBR1

Perikaryon

2.04E-13

TH,DRD2,NTRK2,ESR1,ESR2,CNTNAP2,GRIA2,GRIA3,GRIK2, GRIK3,SLC1A1,CRH,BDNF,NPY,OPRM1

Asymmetric synapse

6.82E-12

DRD1,DRD2,DRD3,NRCAM,MAP2,NTRK2,ARC,SYP, GRIA2,GRIA3,DLG4,GRIK2,GRIN2B,CTNNB1,

NR3C1,GRM5,SLC1A1,HOMER1

Neuron to neuron synapse

1.87E-11

DRD1,DRD2,DRD3,NRCAM,MAP2,NTRK2,ARC,SYP,GRIA2, GRIA3,DLG4,GRIK2,GRIN2B,CTNNB1,

NR3C1,GRM5,SLC1A1,HOMER1

Receptor complex

3.58E-10

GABRG2,HTR1B,HTR2A,HTR3A,NTRK1,NTRK2,NTRK3,GRIA2,GRIA3,DLG4,GRIK2,GRIK3, GRIN2B,HTR3B,

GDNF,IL6,GABBR1,GABRA1

GABA-ergic synapse

5.15E-10

GABRG2,DRD1,DRD2,DRD3,HTR1A,DRD4,NRXN3,NRXN1,GABBR1,GABRA1