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Table 3 Association between Antipsychotic medication and cognitive function

From: Effects of antipsychotic and anticholinergic medications on cognition in chronic patients with schizophrenia

 

Second generation antipsychotics

First generation antipsychotics

No

Yes

No

Yes

Mean ± SE

Mean ± SE

Mean ± SE

Mean ± SE

BACS (global score)

-2.86 ± 0.15

-2.86 ± 0.14

-2.87 ± 0.25

-2.86 ± 0.12

p-value

0.979

0.959

Verbal memory (List learning)

-2.10 ± 0.14

-2.13 ± 0.13

-2.10 ± 0.22

-2.12 ± 0.11

p-value

0.854

0.943

Working memory (Digit sequencing)

-2.05 ± 0.17

-1.87 ± 0.16

-2.15 ± 0.27

-1.90 ± 0.13

p-value

0.455

0.431

Motor speed (Token motor task)

-2.34 ± 0.13

-2.38 ± 0.12

-2.29 ± 0.21

-2.38 ± 0.10

p-value

0.819

0.724

Verbal fluency (Semantic, alphabetical)

-1.43 ± 0.13

-1.59 ± 0.12

-1.58 ± 0.21

-1.50 ± 0.10

p-value

0.394

0.725

Attention and speed of information processing (Symbol coding)

-2.44 ± 0.16

-2.38 ± 0.15

-2.36 ± 0.25

-2.43 ± 0.12

p-value

0.803

0.815

Executive function (Tower of London)

-2.30 ± 0.29

-1.96 ± 0.27

-2.31 ± 0.47

-2.07 ± 0.22

p-value

0.415

0.661

  1. Note: the association between the antipsychotics used and the BACS total score and subtests was adjusted for treatment duration, illness length, and chlorpromazine equivalent dose