Examining the usefulness of the brain network marker program using fMRI for the diagnosis and stratification of major depressive disorder: a non-randomized study protocol

Table 1 Schedule of escitalopram group and usual care group

Timing Item	Registration date	First measurement date of the MRI	Outpatient examination
Timing Item	Registration date	First measurement date of the MRI	Consultation day	After 6 weeks	After 6 months
Schedule	-1 week	0 week	N/A^b	6th week	24th week
Allowance from the specified date	± 1 week	0		± 2 weeks	± 4 weeks
Consent	○
Background information	○
PHQ-9	○			○	○
BDI-II	○		○	○	○
DSM-5 (MINI)	○
HRSD		○		○	○
YMRS		〇		〇	〇
SHAPS, PANAS		○		○	○
NEO-FFI, CATS	○^a
JART, handedness		○
MRI		○		○	○
Medication status	○	○	○	○	○
Evaluation of adverse events	○	○	○	○	○

^aIt will be distributed on the day of consent acquisition and can be collected at week 0
^bNo interval is specified to match the schedule of usual medical care
BDI-II Beck Depression Inventory-II, CATS Child Abuse and Trauma Scale, DSM-5 Diagnostic and Statistical Manual of Mental Disorders 5th edition, HRSD Hamilton Rating Scale for Depression, JART Japanese Adult Reading Test, MINI Mini-International Neuropsychiatric Interview, Neo-FFI Neo-Five-Factor Inventory, PANAS Positive and Negative Affect Schedule, PHQ-9 Patient Health Questionnaire-9, SHAPS Snaith-Hamilton Pleasure Scale, YMRS Young Mania Rating Scale, HRSD Hamilton Rating Scale for Depression

ISSN: 1471-244X