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Fig. 2 | BMC Psychiatry

Fig. 2

From: Immunological evaluation of patients with Alzheimer's disease based on mitogen-stimulated cytokine productions and mitochondrial DNA indicators

Fig. 2

PBMCs genome methylation and hydroxymethylation levels, nuclear DNA damages and mitochondrial DNA damages, Citrate synthase and cytochrome C oxidase activities in PBMCs in 90 AD patients and 90 healthy individuals. Methylated DNA Quantification Kits were used to detect PBMCs genome methylation (A) and hydroxymethylation (B) levels. Long amplicon real-time quantitative PCR was used to evaluate the nuclear DNA (C) and mitochondrial DNA (D) integrity in AD patients. Higher mitochondrial DNA damage was found in AD patients. Citrate synthase (E) and cytochrome C oxidase (F) activities in plasma were detected using qPCR and ELISA kits. Citrate synthase activity was reduced in AD patients. * means significant difference to control (P < 0.05)

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