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Table 1 Characteristics of included systematic reviews

From: Risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 mortality in people with pre-existing mental disorders: an umbrella review

Author, year

Design

Timeframe covered by bibliographic search

Design of included studies

Population / comparator

Countries

Effect size estimation methods

Number of included Studies

Outcomes

Ceban 2021

Systematic review with meta-analysis

From inception to February 1, 2021

Case-control and cohort studies

People with a mood disorder / people without mood disorders

USA, South Korea, Spain, Italy, Turkey, UK, Israel

Random effect model pooling adjusted and crude ORs. Preference given to adjusted ORs when available. Subgroups analyses according to adjustment status

21

(15 aOR, 6 crude ORs)

1- Susceptibility (laboratory testing, ICD-10, EHR, and/or clinical judgment)

2- Hospitalization

3- Occurrence of severe events (includes oxygen therapy)

4- Death

Fond 2021

Systematic review with meta-analysis

From inception to February 12, 2021

Population-based cohort studies based on medico-administrative health databases or a health care data warehouse

People with any mental disorder (includes substance abuse disorders and ADHD) / people without a mental disorder

Denmark, France, Israel, South Korea, Spain, UK, USA

Random effects models, separate pooling of aORs and crude ORs

21

1- Mortality

2- ICU admission

Fornaro 2021

Scoping review (no meta-analysis)

From inception up to April 24, 2021

Cross-sectional, prospective cohort, retrospective cohort studies, case reports/series

People with Bipolar disorder / NA

Italy, UK, Australia, USA, the Netherlands, India, China

 

14

Identified themes: 1- Impact of COVID-19-related stressors on BD

2- Impact of COVID-19 on mental health service utilization among people with BD

3- Impact of BD on the risk of acquiring SARS-cov-2 infection

4- Engagement in preventative behaviors among people with BD

Karaoulanis 2021

Systematic review without meta-analysis

From inception up to 21 March 2021

Unreported

People with Schizophrenia / people without Schizophrenia

USA, Korea, France, Israel

 

7

1- Susceptibility (being infected)

2- Mortality

Lemieux 2020

Rapid review

From December 2019 up 18 August 2020

Opinion pieces by experts (editorials, letters to the editor, position papers and other correspondences), rapid literature reviews, narrative (i.e., Non-systematic) literature reviews, empirical studies (surveys and descriptive/case studies)

People with mental illness in secure settings / NA

USA, China, Italy, UK, France, Germany, Ireland, Singapore, Brazil, Canada, Spain, Australia, India, Israel, Poland, New Zealand, South Korea, Scandinavia, Switzerland

 

69

Narrative review on strategies, challenges and recommendations for dealing with the COVID-19 outbreak in secure settings for persons with mental illness

Liu 2021

Systematic review with meta-analysis

From inception to January 16, 2021

Cohort, case-control, cross-sectional studies and case series

People with mental disorders (includes sleep disorders and ADHD) / people without mental disorders

USA, Italy, Korea, UK, China, Iran, Brazil, Spain, Turkey, Israel, Switzerland, the Netherlands, Denmark, France, Belgium, Sweden, Russia, Peru, Germany, Malaysia, Poland

Random effect models pooling adjusted and crude ORs. Subgroups analyses according to adjustment status for ‘any mental disorder’ population only

149

1- Susceptibility (positive laboratory results, diagnosis in conjunction with clinical presentation)

2- Illness severity (hospitalization, ICU admission, or requirement for other special treatment (e.g., oxygen therapy, mechanical ventilator, extracorporeal membrane oxygenation, and cardiopulmonary resuscitation))

3- Death

Murphy 2021

Scoping review

From 1 January to 31 December 2020

Primary research papers including qualitative, quantitative and mixed methods study designs

People with mental disorders / NA

Italy, USA, China, Canada, Germany, Spain, UK, Ireland, Australia, India, Switzerland, France, Iran, Turkey, Poland, Pakistan, Bosnia and Herzegovina

 

30

Narrative review of factors influencing health outcomes in people with pre-existing mental health conditions during the pandemic; impact of the pandemic on the health of people with pre-existing mental health conditions; Strategies or measure to support people with pre-existing mental health conditions during the pandemic

Toubasi 2021

Systematic review with meta-analysis

From inception to 15 February 2021

Cohort, case control

People with mental disorders / people without mental disorders

UK, Japan, South Korea, France, Scotland, Israel, USA

Random effects models, pooling both adjusted and crude ORs. Sensitivity analysis including aOR only

16 (aOR: 5)

1- Death or Severe illness (ICU admission and ventilation)

Vai 2021

Systematic review with meta-analysis

From 1 January 2020 to 5 March 2021

Cross-sectional, longitudinal studies

People with mental disorders (includes substance use disorders and intellectual disabilities)/ people without mental disorders

UK, Japan, South Korea, France, Scotland, Sweden, USA

Random effects models pooling crude ORs. Sensitivity analysis polling aORs only.

23

1- Death

2- Hospitalization

3- ICU admission

  1. aORs: adjusted Odds Ratios, ADHD: Attention-deficit hyperactivity disorder, BP: Bipolar disorder, ICU: intensive care unit, NA: Not applicable, ORs: Odds Ratios, UK: United Kingdom, USA: United States of America,