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Table 4 Multivariate logistic regression analysis of neutropenia and leukocytosis (final model after variable selection of backward elimination)

From: Valproate-related neutropenia and lithium-related leukocytosis in patients treated with clozapine: a retrospective cohort study

 

Neutropenia

Leukocytosis

 

Odds ratio

95%CI

P value

Odds ratio

95%CI

P value

CLO group

1

  

1

  

CLO + VAL group

3.49

1.91–6.39

< 0.001

0.92

0.69–1.22

0.548

CLO + Li group

NAa

NAa

NAa

3.39

1.72–6.68

< 0.001

CLO +VAL + Li group

NAa

NAa

NAa

1.14

0.46–2.83

0.781

Age

1.03

1.01–1.06

0.007

0.97

0.95–0.98

< 0.001

Sex b

   

1.39

1.08–1.79

.012 b

Clozapine daily

dosage c

   

1.11

1.02–1.22

0.015

Benzodiazepine

   

1.64

1.27–2.13

< 0.001

  1. Bold and underlined p values indicate a statistically significant difference
  2. Values obtained using logistic regression, with backward elimination and a threshold of 0.1. Variables used in the first step of the logistic regression were age, clozapine dosage, sex, antipsychotics use, antidepressants use, anticholinergics use, benzodiazepine use, antihypertensives use, antidiabetics use, antihyperlipidemics use, and antiepileptics use. Omnibus Tests of Model Coefficients revealed statistical significance
  3. a: No patient reported to have neutropenia when using clozapine and lithium concomitantly; b: Reference was set at female; c: Clozapine daily dosage: at increasing intervals of 100 milligrams per day
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BMC Psychiatry

ISSN: 1471-244X

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